DNA damage signaling guards against perturbation of cyclin D1 expression triggered by low-dose long-term fractionated radiation

Cyclin D1 expression is precisely controlled during cell-cycle progression. However, repeated exposure to low-dose fractionated radiation (FR) abrogates cell cycle-dependent cyclin D1 degradation by constitutive activation of AKT survival signaling in normal human fibroblasts. The resulting abnormal...

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Detalles Bibliográficos
Autores principales: Shimura, T, Kobayashi, J, Komatsu, K, Kunugita, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275562/
https://www.ncbi.nlm.nih.gov/pubmed/25486524
http://dx.doi.org/10.1038/oncsis.2014.48

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