Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats

BACKGROUND: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection. FINDINGS: Here, we analyse the receptor usage of viral variants in the blood...

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Autores principales: Bęczkowski, Paweł M, Techakriengkrai, Navapon, Logan, Nicola, McMonagle, Elizabeth, Litster, Annette, Willett, Brian J, Hosie, Margaret J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275942/
https://www.ncbi.nlm.nih.gov/pubmed/25430586
http://dx.doi.org/10.1186/s12977-014-0095-7
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author Bęczkowski, Paweł M
Techakriengkrai, Navapon
Logan, Nicola
McMonagle, Elizabeth
Litster, Annette
Willett, Brian J
Hosie, Margaret J
author_facet Bęczkowski, Paweł M
Techakriengkrai, Navapon
Logan, Nicola
McMonagle, Elizabeth
Litster, Annette
Willett, Brian J
Hosie, Margaret J
author_sort Bęczkowski, Paweł M
collection PubMed
description BACKGROUND: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection. FINDINGS: Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression. CONCLUSIONS: These findings are consistent with a shift in CRD2 of CD134 usage with disease progression. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12977-014-0095-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-42759422014-12-25 Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats Bęczkowski, Paweł M Techakriengkrai, Navapon Logan, Nicola McMonagle, Elizabeth Litster, Annette Willett, Brian J Hosie, Margaret J Retrovirology Short Report BACKGROUND: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection. FINDINGS: Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression. CONCLUSIONS: These findings are consistent with a shift in CRD2 of CD134 usage with disease progression. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12977-014-0095-7) contains supplementary material, which is available to authorized users. BioMed Central 2014-11-28 /pmc/articles/PMC4275942/ /pubmed/25430586 http://dx.doi.org/10.1186/s12977-014-0095-7 Text en © Bęczkowski et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Bęczkowski, Paweł M
Techakriengkrai, Navapon
Logan, Nicola
McMonagle, Elizabeth
Litster, Annette
Willett, Brian J
Hosie, Margaret J
Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats
title Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats
title_full Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats
title_fullStr Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats
title_full_unstemmed Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats
title_short Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats
title_sort emergence of cd134 cysteine-rich domain 2 (crd2)-independent strains of feline immunodeficiency virus (fiv) is associated with disease progression in naturally infected cats
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275942/
https://www.ncbi.nlm.nih.gov/pubmed/25430586
http://dx.doi.org/10.1186/s12977-014-0095-7
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