Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits

Background: Mendelian randomization studies have so far restricted attention to linear associations relating the genetic instrument to the exposure, and the exposure to the outcome. In some cases, however, observational data suggest a non-linear association between exposure and outcome. For example,...

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Detalles Bibliográficos
Autores principales: Silverwood, Richard J, Holmes, Michael V, Dale, Caroline E, Lawlor, Debbie A, Whittaker, John C, Smith, George Davey, Leon, David A, Palmer, Tom, Keating, Brendan J, Zuccolo, Luisa, Casas, Juan P, Dudbridge, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genetic Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276061/
https://www.ncbi.nlm.nih.gov/pubmed/25192829
http://dx.doi.org/10.1093/ije/dyu187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276061/
https://www.ncbi.nlm.nih.gov/pubmed/25192829
http://dx.doi.org/10.1093/ije/dyu187

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