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Hypoglycemia with a large retroperitoneal mass – Case report

INTRODUCTION: Retroperitoneal sarcomas have rarely been reported to secrete insulin-growth factor II (IGF-II) and produce an enigmatic hypoglycemia. IGF-II-secreting sarcomas represent an extremely rare subset of soft tissue tumors, and reports are limited to a handful of cases. PRESENTATION OF CASE...

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Autores principales: Hawasli, Jennifer A., Hopping, Jacob R., Hsueh, Eddy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276271/
https://www.ncbi.nlm.nih.gov/pubmed/25437682
http://dx.doi.org/10.1016/j.ijscr.2014.11.013
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author Hawasli, Jennifer A.
Hopping, Jacob R.
Hsueh, Eddy C.
author_facet Hawasli, Jennifer A.
Hopping, Jacob R.
Hsueh, Eddy C.
author_sort Hawasli, Jennifer A.
collection PubMed
description INTRODUCTION: Retroperitoneal sarcomas have rarely been reported to secrete insulin-growth factor II (IGF-II) and produce an enigmatic hypoglycemia. IGF-II-secreting sarcomas represent an extremely rare subset of soft tissue tumors, and reports are limited to a handful of cases. PRESENTATION OF CASE: The authors present the case of hypoglycemia due to an IGF-II-secreting retroperitoneal sarcoma that was successfully treated by complete surgical resection. This report describes the diagnosis and management of this rare syndrome with 1-year follow-up and a review of the literature. DISCUSSION: Steroid and growth hormone therapies also have efficacy to treat this hypoglycemia in some patients. However, outcomes appear better if combined with surgical resection. CONCLUSIONS: The findings of this case report and review of the literature support a primary role for complete tumor resection to address tumor-induced hypoglycemia.
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spelling pubmed-42762712014-12-28 Hypoglycemia with a large retroperitoneal mass – Case report Hawasli, Jennifer A. Hopping, Jacob R. Hsueh, Eddy C. Int J Surg Case Rep Article INTRODUCTION: Retroperitoneal sarcomas have rarely been reported to secrete insulin-growth factor II (IGF-II) and produce an enigmatic hypoglycemia. IGF-II-secreting sarcomas represent an extremely rare subset of soft tissue tumors, and reports are limited to a handful of cases. PRESENTATION OF CASE: The authors present the case of hypoglycemia due to an IGF-II-secreting retroperitoneal sarcoma that was successfully treated by complete surgical resection. This report describes the diagnosis and management of this rare syndrome with 1-year follow-up and a review of the literature. DISCUSSION: Steroid and growth hormone therapies also have efficacy to treat this hypoglycemia in some patients. However, outcomes appear better if combined with surgical resection. CONCLUSIONS: The findings of this case report and review of the literature support a primary role for complete tumor resection to address tumor-induced hypoglycemia. Elsevier 2014-11-11 /pmc/articles/PMC4276271/ /pubmed/25437682 http://dx.doi.org/10.1016/j.ijscr.2014.11.013 Text en © 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Hawasli, Jennifer A.
Hopping, Jacob R.
Hsueh, Eddy C.
Hypoglycemia with a large retroperitoneal mass – Case report
title Hypoglycemia with a large retroperitoneal mass – Case report
title_full Hypoglycemia with a large retroperitoneal mass – Case report
title_fullStr Hypoglycemia with a large retroperitoneal mass – Case report
title_full_unstemmed Hypoglycemia with a large retroperitoneal mass – Case report
title_short Hypoglycemia with a large retroperitoneal mass – Case report
title_sort hypoglycemia with a large retroperitoneal mass – case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276271/
https://www.ncbi.nlm.nih.gov/pubmed/25437682
http://dx.doi.org/10.1016/j.ijscr.2014.11.013
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