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Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers

Chlorpyrifos (CPF) is a commonly used organophosphate insecticide (OP). In adults, exposure to OPs has been inconsistently associated with reduced lung function. OP exposure and lung function has not been assessed in adolescents. The objective of this study was to assess CPF exposure and lung functi...

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Autores principales: Callahan, Catherine L., Al-Batanony, Manal, Ismail, Ahmed A., Abdel-Rasoul, Gaafar, Hendy, Olfat, Olson, James R., Rohlman, Diane S., Bonner, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276666/
https://www.ncbi.nlm.nih.gov/pubmed/25522051
http://dx.doi.org/10.3390/ijerph111213117
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author Callahan, Catherine L.
Al-Batanony, Manal
Ismail, Ahmed A.
Abdel-Rasoul, Gaafar
Hendy, Olfat
Olson, James R.
Rohlman, Diane S.
Bonner, Matthew R.
author_facet Callahan, Catherine L.
Al-Batanony, Manal
Ismail, Ahmed A.
Abdel-Rasoul, Gaafar
Hendy, Olfat
Olson, James R.
Rohlman, Diane S.
Bonner, Matthew R.
author_sort Callahan, Catherine L.
collection PubMed
description Chlorpyrifos (CPF) is a commonly used organophosphate insecticide (OP). In adults, exposure to OPs has been inconsistently associated with reduced lung function. OP exposure and lung function has not been assessed in adolescents. The objective of this study was to assess CPF exposure and lung function among Egyptian adolescents. We conducted a 10-month study of male adolescent pesticide applicators (n = 38) and non-applicators of similar age (n = 24). Urinary 3,5,6-trichloro-2-pyridinol (TPCy), a CPF-specific metabolite, was analyzed in specimens collected throughout the study. Spirometry was performed twice after pesticide application: day 146, when TCPy levels were elevated and day 269, when TCPy levels were near baseline. Applicators had higher levels of TCPy (mean cumulative TCPy day 146 = 33,217.6; standard deviation (SD) = 49,179.3) than non-applicators (mean cumulative TCPy day 146 = 3290.8; SD = 3994.9). Compared with non-applicators, applicators had higher odds of reporting wheeze, odds ratio = 3.41 (95% CI: 0.70; 17.41). Cumulative urinary TCPy was inversely associated with spirometric measurements at day 146, but not at day 269. Although generally non-significant, results were consistent with an inverse association between exposure to CPF and lung function.
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spelling pubmed-42766662015-01-08 Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers Callahan, Catherine L. Al-Batanony, Manal Ismail, Ahmed A. Abdel-Rasoul, Gaafar Hendy, Olfat Olson, James R. Rohlman, Diane S. Bonner, Matthew R. Int J Environ Res Public Health Article Chlorpyrifos (CPF) is a commonly used organophosphate insecticide (OP). In adults, exposure to OPs has been inconsistently associated with reduced lung function. OP exposure and lung function has not been assessed in adolescents. The objective of this study was to assess CPF exposure and lung function among Egyptian adolescents. We conducted a 10-month study of male adolescent pesticide applicators (n = 38) and non-applicators of similar age (n = 24). Urinary 3,5,6-trichloro-2-pyridinol (TPCy), a CPF-specific metabolite, was analyzed in specimens collected throughout the study. Spirometry was performed twice after pesticide application: day 146, when TCPy levels were elevated and day 269, when TCPy levels were near baseline. Applicators had higher levels of TCPy (mean cumulative TCPy day 146 = 33,217.6; standard deviation (SD) = 49,179.3) than non-applicators (mean cumulative TCPy day 146 = 3290.8; SD = 3994.9). Compared with non-applicators, applicators had higher odds of reporting wheeze, odds ratio = 3.41 (95% CI: 0.70; 17.41). Cumulative urinary TCPy was inversely associated with spirometric measurements at day 146, but not at day 269. Although generally non-significant, results were consistent with an inverse association between exposure to CPF and lung function. MDPI 2014-12-16 2014-12 /pmc/articles/PMC4276666/ /pubmed/25522051 http://dx.doi.org/10.3390/ijerph111213117 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Callahan, Catherine L.
Al-Batanony, Manal
Ismail, Ahmed A.
Abdel-Rasoul, Gaafar
Hendy, Olfat
Olson, James R.
Rohlman, Diane S.
Bonner, Matthew R.
Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers
title Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers
title_full Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers
title_fullStr Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers
title_full_unstemmed Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers
title_short Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers
title_sort chlorpyrifos exposure and respiratory health among adolescent agricultural workers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276666/
https://www.ncbi.nlm.nih.gov/pubmed/25522051
http://dx.doi.org/10.3390/ijerph111213117
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