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Heparan Sulfate Inhibits Hematopoietic Stem and Progenitor Cell Migration and Engraftment in Mucopolysaccharidosis I

Mucopolysaccharidosis I Hurler (MPSI-H) is a pediatric lysosomal storage disease caused by genetic deficiencies in IDUA, coding for α-l-iduronidase. Idua(−/−) mice share similar clinical pathology with patients, including the accumulation of the undegraded glycosaminoglycans (GAGs) heparan sulfate (...

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Detalles Bibliográficos
Autores principales:	Watson, H. Angharad, Holley, Rebecca J., Langford-Smith, Kia J., Wilkinson, Fiona L., van Kuppevelt, Toin H., Wynn, Robert F., Wraith, J. Edmond, Merry, Catherine L. R., Bigger, Brian W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Glycobiology and Extracellular Matrices
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276882/ https://www.ncbi.nlm.nih.gov/pubmed/25359774 http://dx.doi.org/10.1074/jbc.M114.599944

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