Multiple Drugs Compete for Transport via the Plasmodium falciparum Chloroquine Resistance Transporter at Distinct but Interdependent Sites

Mutations in the “chloroquine resistance transporter” (PfCRT) are a major determinant of drug resistance in the malaria parasite Plasmodium falciparum. We have previously shown that mutant PfCRT transports the antimalarial drug chloroquine away from its target, whereas the wild-type form of PfCRT do...

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Detalles Bibliográficos
Autores principales: Bellanca, Sebastiano, Summers, Robert L., Meyrath, Max, Dave, Anurag, Nash, Megan N., Dittmer, Martin, Sanchez, Cecilia P., Stein, Wilfred D., Martin, Rowena E., Lanzer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276893/
https://www.ncbi.nlm.nih.gov/pubmed/25378409
http://dx.doi.org/10.1074/jbc.M114.614206

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