Cargando…

Natural and Synthetic Modulators of the TRPM7 Channel

Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a bi-functional protein comprising a TRP ion channel segment linked to an α-type protein kinase domain. Genetic inactivation of TRPM7 revealed its central role in magnesium metabolism, cell motility, proliferation and differ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chubanov, Vladimir, Schäfer, Sebastian, Ferioli, Silvia, Gudermann, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276914/ https://www.ncbi.nlm.nih.gov/pubmed/25437439 http://dx.doi.org/10.3390/cells3041089

Ejemplares similares

TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg·ATP
por: Ferioli, Silvia, et al.
Publicado: (2017)

Mapping TRPM7 Function by NS8593
por: Chubanov, Vladimir, et al.
Publicado: (2020)

Drosophila TRPM Channel Is Essential for the Control of Extracellular Magnesium Levels
por: Hofmann, Thomas, et al.
Publicado: (2010)

Structural mechanism of TRPM7 channel regulation by intracellular magnesium
por: Schmidt, Eva, et al.
Publicado: (2022)

Structural mechanisms of TRPM7 activation and inhibition
por: Nadezhdin, Kirill D., et al.
Publicado: (2023)

TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells
por: Kaske, Silke, et al.
Publicado: (2007)

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics
por: Kollewe, Astrid, et al.
Publicado: (2021)

Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture
por: Stritt, Simon, et al.
Publicado: (2016)

TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival
por: Mittermeier, Lorenz, et al.
Publicado: (2019)

Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice
por: Ryazanova, Lillia V., et al.
Publicado: (2014)

TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut
por: Romagnani, Andrea, et al.
Publicado: (2017)

TRPM7 kinase is required for insulin production and compensatory islet responses during obesity
por: Khajavi, Noushafarin, et al.
Publicado: (2023)

The Pathophysiologic Roles of TRPM7 Channel
por: Park, Hyun Soo, et al.
Publicado: (2014)

TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt
por: Rios, Francisco J., et al.
Publicado: (2022)

Inactivation of TRPM7 Kinase Targets AKT Signaling and Cyclooxygenase-2 Expression in Human CML Cells
por: Hoeger, Birgit, et al.
Publicado: (2023)

Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation
por: Vydra Bousova, Kristyna, et al.
Publicado: (2023)

Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 1: Modulation of TRPM4
por: Kovács, Zsigmond Máté, et al.
Publicado: (2022)

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival
por: Chubanov, Vladimir, et al.
Publicado: (2016)

TRPM7 is a molecular substrate of ATP-evoked P2X7-like currents in tumor cells
por: Nörenberg, Wolfgang, et al.
Publicado: (2016)

TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets
por: Yee, Nelson S., et al.
Publicado: (2012)

Functional Characterization of Homo- and Heteromeric Channel Kinases TRPM6 and TRPM7
por: Li, Mingjiang, et al.
Publicado: (2006)

TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation
por: Izquierdo, Carolina, et al.
Publicado: (2021)

Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 2: TRPM4 in Health and Disease
por: Dienes, Csaba, et al.
Publicado: (2021)

TRPM Family Channels in Cancer
por: Hantute-Ghesquier, Aline, et al.
Publicado: (2018)

TRPM Channels in Human Diseases
por: Jimenez, Ivanka, et al.
Publicado: (2020)

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis
por: Nadolni, Wiebke, et al.
Publicado: (2018)

Inorganic Polyphosphate Modulates TRPM8 Channels
por: Zakharian, Eleonora, et al.
Publicado: (2009)

Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer
por: Yee, Nelson S., et al.
Publicado: (2014)

TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer
por: Cordier, Clément, et al.
Publicado: (2021)

TRPM8 Channels and Dry Eye
por: Yang, Jee Myung, et al.
Publicado: (2018)

On the Connections between TRPM Channels and SOCE
por: Souza Bomfim, Guilherme H., et al.
Publicado: (2022)

TRPM7, Magnesium, and Signaling
por: Zou, Zhi-Guo, et al.
Publicado: (2019)

Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases
por: Cai, Na, et al.
Publicado: (2017)

Structure of human TRPM8 channel
por: Palchevskyi, Sergii, et al.
Publicado: (2023)

N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation
por: Zhang, Zheng, et al.
Publicado: (2014)

Taste Receptor Activation in Tracheal Brush Cells by Denatonium Modulates ENaC Channels via Ca(2+), cAMP and ACh
por: Hollenhorst, Monika I., et al.
Publicado: (2022)

Potential of the TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension
por: Hiraishi, Keizo, et al.
Publicado: (2022)

VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
por: Ghosh, Debapriya, et al.
Publicado: (2016)

Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis
por: Jiménez-Dinamarca, Ivanka, et al.
Publicado: (2023)

On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications
por: Ciaglia, Tania, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4bn1g04rdhs1toiivn06b6vh3s