Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line

Memantine is a non-competitive antagonist of the N-methyl-d-aspartate (NMDA) receptor, and is an approved drug for the treatment of moderate-to-severe Alzheimer’s disease. We identified a mouse strain with a naturally occurring mutation and an ataxic phenotype that presents with severe leg cramps. T...

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Detalles Bibliográficos
Autores principales: Kumagai, Ayako, Fujita, Akira, Yokoyama, Tomoki, Nonobe, Yuki, Hasaba, Yasuhiro, Sasaki, Tsutomu, Itoh, Yumi, Koura, Minako, Suzuki, Osamu, Adachi, Shigeki, Ryo, Haruko, Kohara, Arihiro, Tripathi, Lokesh P., Sanosaka, Masato, Fukushima, Toshiki, Takahashi, Hiroyuki, Kitagawa, Kazuo, Nagaoka, Yasuo, Kawahara, Hidehisa, Mizuguchi, Kenji, Nomura, Taisei, Matsuda, Junichiro, Tabata, Toshihide, Takemori, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276928/
https://www.ncbi.nlm.nih.gov/pubmed/25513882
http://dx.doi.org/10.3390/genes5041095

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