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Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance

Emerging evidence indicates an association between obesity, metformin use and reduced vitamin B12 status, which can have serious hematologic, neurologic and psychiatric consequences. This study aimed to examine B12 status in obese adolescents with pre-diabetes and/or clinical features of insulin res...

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Autores principales: Ho, Mandy, Halim, Jocelyn H., Gow, Megan L., El-Haddad, Nouhad, Marzulli, Teresa, Baur, Louise A., Cowell, Chris T., Garnett, Sarah P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276987/
https://www.ncbi.nlm.nih.gov/pubmed/25486369
http://dx.doi.org/10.3390/nu6125611
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author Ho, Mandy
Halim, Jocelyn H.
Gow, Megan L.
El-Haddad, Nouhad
Marzulli, Teresa
Baur, Louise A.
Cowell, Chris T.
Garnett, Sarah P.
author_facet Ho, Mandy
Halim, Jocelyn H.
Gow, Megan L.
El-Haddad, Nouhad
Marzulli, Teresa
Baur, Louise A.
Cowell, Chris T.
Garnett, Sarah P.
author_sort Ho, Mandy
collection PubMed
description Emerging evidence indicates an association between obesity, metformin use and reduced vitamin B12 status, which can have serious hematologic, neurologic and psychiatric consequences. This study aimed to examine B12 status in obese adolescents with pre-diabetes and/or clinical features of insulin resistance. Serum B12 was measured using chemiluminescence immunoassay in 103 (43 male, 60 female) obese (mean body mass index (BMI) z-score ± SD (2.36 ± 0.29)), adolescents aged 10 to 17 years, median (range) insulin sensitivity index of 1.27 (0.27 to 3.38) and 13.6% had pre-diabetes. Low B12 (<148 pmol/L) was identified in eight (7.8%) and borderline status (148 to 221 pmol/L) in an additional 25 (24.3%) adolescents. Adolescents with borderline B12 concentrations had higher BMI z-scores compared to those with normal concentrations (2.50 ± 0.22 vs. 2.32 ± 0.30, p = 0.008) or those with low B12 concentration (2.50 ± 0.22 vs. 2.27 ± 0.226, p = 0.041). In conclusion, nearly a third of obese adolescents with clinical insulin resistance had a low or borderline serum B12 status. Therefore, further investigations are warranted to explore the cause and the impact of low B12 status in obese pediatric populations.
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spelling pubmed-42769872015-01-15 Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance Ho, Mandy Halim, Jocelyn H. Gow, Megan L. El-Haddad, Nouhad Marzulli, Teresa Baur, Louise A. Cowell, Chris T. Garnett, Sarah P. Nutrients Communication Emerging evidence indicates an association between obesity, metformin use and reduced vitamin B12 status, which can have serious hematologic, neurologic and psychiatric consequences. This study aimed to examine B12 status in obese adolescents with pre-diabetes and/or clinical features of insulin resistance. Serum B12 was measured using chemiluminescence immunoassay in 103 (43 male, 60 female) obese (mean body mass index (BMI) z-score ± SD (2.36 ± 0.29)), adolescents aged 10 to 17 years, median (range) insulin sensitivity index of 1.27 (0.27 to 3.38) and 13.6% had pre-diabetes. Low B12 (<148 pmol/L) was identified in eight (7.8%) and borderline status (148 to 221 pmol/L) in an additional 25 (24.3%) adolescents. Adolescents with borderline B12 concentrations had higher BMI z-scores compared to those with normal concentrations (2.50 ± 0.22 vs. 2.32 ± 0.30, p = 0.008) or those with low B12 concentration (2.50 ± 0.22 vs. 2.27 ± 0.226, p = 0.041). In conclusion, nearly a third of obese adolescents with clinical insulin resistance had a low or borderline serum B12 status. Therefore, further investigations are warranted to explore the cause and the impact of low B12 status in obese pediatric populations. MDPI 2014-12-04 /pmc/articles/PMC4276987/ /pubmed/25486369 http://dx.doi.org/10.3390/nu6125611 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ho, Mandy
Halim, Jocelyn H.
Gow, Megan L.
El-Haddad, Nouhad
Marzulli, Teresa
Baur, Louise A.
Cowell, Chris T.
Garnett, Sarah P.
Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance
title Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance
title_full Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance
title_fullStr Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance
title_full_unstemmed Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance
title_short Vitamin B12 in Obese Adolescents with Clinical Features of Insulin Resistance
title_sort vitamin b12 in obese adolescents with clinical features of insulin resistance
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276987/
https://www.ncbi.nlm.nih.gov/pubmed/25486369
http://dx.doi.org/10.3390/nu6125611
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