Cargando…

Application of Coenzyme Q10 for Accelerating Soft Tissue Wound Healing after Tooth Extraction in Rats

Accelerating wound healing after tooth extraction is beneficial in dental treatment. Application of antioxidants, such as reduced coenzyme Q10 (rCoQ10), may promote wound healing after tooth extraction. In this study, we examined the effects of topical application of rCoQ10 on wound healing after to...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoneda, Toshiki, Tomofuji, Takaaki, Kawabata, Yuya, Ekuni, Daisuke, Azuma, Tetsuji, Kataoka, Kota, Kunitomo, Muneyoshi, Morita, Manabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276996/
https://www.ncbi.nlm.nih.gov/pubmed/25514392
http://dx.doi.org/10.3390/nu6125756
_version_ 1782350334210867200
author Yoneda, Toshiki
Tomofuji, Takaaki
Kawabata, Yuya
Ekuni, Daisuke
Azuma, Tetsuji
Kataoka, Kota
Kunitomo, Muneyoshi
Morita, Manabu
author_facet Yoneda, Toshiki
Tomofuji, Takaaki
Kawabata, Yuya
Ekuni, Daisuke
Azuma, Tetsuji
Kataoka, Kota
Kunitomo, Muneyoshi
Morita, Manabu
author_sort Yoneda, Toshiki
collection PubMed
description Accelerating wound healing after tooth extraction is beneficial in dental treatment. Application of antioxidants, such as reduced coenzyme Q10 (rCoQ10), may promote wound healing after tooth extraction. In this study, we examined the effects of topical application of rCoQ10 on wound healing after tooth extraction in rats. After maxillary first molars were extracted, male Fischer 344 rats (8 weeks old) (n = 27) received topical application of ointment containing 5% rCoQ10 (experimental group) or control ointment (control group) to the sockets for 3 or 8 days (n = 6–7/group). At 3 days after extraction, the experimental group showed higher collagen density and lower numbers of polymorphonuclear leukocytes in the upper part of socket, as compared to the control group (p < 0.05). Gene expression of interleukin-1β, tumor necrosis factor-α and nuclear factor-κB were also lower in the experimental group than in the control group (p < 0.05). At 8 days after tooth extraction, there were no significant differences in collagen density, number of polymorphonuclear leukocytes and bone fill between the groups. Our results suggest that topical application of rCoQ10 promotes wound healing in the soft tissue of the alveolar socket, but that rCoQ10 has a limited effect on bone remodeling in rats.
format Online
Article
Text
id pubmed-4276996
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-42769962015-01-15 Application of Coenzyme Q10 for Accelerating Soft Tissue Wound Healing after Tooth Extraction in Rats Yoneda, Toshiki Tomofuji, Takaaki Kawabata, Yuya Ekuni, Daisuke Azuma, Tetsuji Kataoka, Kota Kunitomo, Muneyoshi Morita, Manabu Nutrients Article Accelerating wound healing after tooth extraction is beneficial in dental treatment. Application of antioxidants, such as reduced coenzyme Q10 (rCoQ10), may promote wound healing after tooth extraction. In this study, we examined the effects of topical application of rCoQ10 on wound healing after tooth extraction in rats. After maxillary first molars were extracted, male Fischer 344 rats (8 weeks old) (n = 27) received topical application of ointment containing 5% rCoQ10 (experimental group) or control ointment (control group) to the sockets for 3 or 8 days (n = 6–7/group). At 3 days after extraction, the experimental group showed higher collagen density and lower numbers of polymorphonuclear leukocytes in the upper part of socket, as compared to the control group (p < 0.05). Gene expression of interleukin-1β, tumor necrosis factor-α and nuclear factor-κB were also lower in the experimental group than in the control group (p < 0.05). At 8 days after tooth extraction, there were no significant differences in collagen density, number of polymorphonuclear leukocytes and bone fill between the groups. Our results suggest that topical application of rCoQ10 promotes wound healing in the soft tissue of the alveolar socket, but that rCoQ10 has a limited effect on bone remodeling in rats. MDPI 2014-12-10 /pmc/articles/PMC4276996/ /pubmed/25514392 http://dx.doi.org/10.3390/nu6125756 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoneda, Toshiki
Tomofuji, Takaaki
Kawabata, Yuya
Ekuni, Daisuke
Azuma, Tetsuji
Kataoka, Kota
Kunitomo, Muneyoshi
Morita, Manabu
Application of Coenzyme Q10 for Accelerating Soft Tissue Wound Healing after Tooth Extraction in Rats
title Application of Coenzyme Q10 for Accelerating Soft Tissue Wound Healing after Tooth Extraction in Rats
title_full Application of Coenzyme Q10 for Accelerating Soft Tissue Wound Healing after Tooth Extraction in Rats
title_fullStr Application of Coenzyme Q10 for Accelerating Soft Tissue Wound Healing after Tooth Extraction in Rats
title_full_unstemmed Application of Coenzyme Q10 for Accelerating Soft Tissue Wound Healing after Tooth Extraction in Rats
title_short Application of Coenzyme Q10 for Accelerating Soft Tissue Wound Healing after Tooth Extraction in Rats
title_sort application of coenzyme q10 for accelerating soft tissue wound healing after tooth extraction in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276996/
https://www.ncbi.nlm.nih.gov/pubmed/25514392
http://dx.doi.org/10.3390/nu6125756
work_keys_str_mv AT yonedatoshiki applicationofcoenzymeq10foracceleratingsofttissuewoundhealingaftertoothextractioninrats
AT tomofujitakaaki applicationofcoenzymeq10foracceleratingsofttissuewoundhealingaftertoothextractioninrats
AT kawabatayuya applicationofcoenzymeq10foracceleratingsofttissuewoundhealingaftertoothextractioninrats
AT ekunidaisuke applicationofcoenzymeq10foracceleratingsofttissuewoundhealingaftertoothextractioninrats
AT azumatetsuji applicationofcoenzymeq10foracceleratingsofttissuewoundhealingaftertoothextractioninrats
AT kataokakota applicationofcoenzymeq10foracceleratingsofttissuewoundhealingaftertoothextractioninrats
AT kunitomomuneyoshi applicationofcoenzymeq10foracceleratingsofttissuewoundhealingaftertoothextractioninrats
AT moritamanabu applicationofcoenzymeq10foracceleratingsofttissuewoundhealingaftertoothextractioninrats