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Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan

Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10–66 years, a subset of a...

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Autores principales: Ji, Yuelong, Kong, Xiangyi, Wang, Guoying, Hong, Xiumei, Xu, Xin, Chen, Zhu, Bartell, Tami, Xu, Xiping, Tang, Genfu, Hou, Fanfan, Huo, Yong, Wang, Xiaobin, Wang, Binyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277006/
https://www.ncbi.nlm.nih.gov/pubmed/25529062
http://dx.doi.org/10.3390/nu6125900
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author Ji, Yuelong
Kong, Xiangyi
Wang, Guoying
Hong, Xiumei
Xu, Xin
Chen, Zhu
Bartell, Tami
Xu, Xiping
Tang, Genfu
Hou, Fanfan
Huo, Yong
Wang, Xiaobin
Wang, Binyan
author_facet Ji, Yuelong
Kong, Xiangyi
Wang, Guoying
Hong, Xiumei
Xu, Xin
Chen, Zhu
Bartell, Tami
Xu, Xiping
Tang, Genfu
Hou, Fanfan
Huo, Yong
Wang, Xiaobin
Wang, Binyan
author_sort Ji, Yuelong
collection PubMed
description Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10–66 years, a subset of a community-based rural Chinese twin cohort. In addition, we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups. We found that the distribution pattern for Hcy varied by both age and gender. Males had higher Hcy than females across all ages. Elevated Hcy was found in 43% of male adults and 13% of female adults. Moreover, nearly one fifth of children had elevated Hcy. Genetic factors could explain 52%, 36% and 69% of the variation in Hcy concentration among children, male adults and female adults, respectively. The MTHFR C677T variant was significantly associated with Hcy concentrations. Smokers with the TT genotype had the highest Hcy levels. Overall, our results indicate that elevated Hcy is prevalent in the children and adults in this rural Chinese population. The early identification of elevated Hcy will offer a window of opportunity for the primary prevention of CVD and metabolic syndrome.
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spelling pubmed-42770062015-01-15 Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan Ji, Yuelong Kong, Xiangyi Wang, Guoying Hong, Xiumei Xu, Xin Chen, Zhu Bartell, Tami Xu, Xiping Tang, Genfu Hou, Fanfan Huo, Yong Wang, Xiaobin Wang, Binyan Nutrients Article Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10–66 years, a subset of a community-based rural Chinese twin cohort. In addition, we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups. We found that the distribution pattern for Hcy varied by both age and gender. Males had higher Hcy than females across all ages. Elevated Hcy was found in 43% of male adults and 13% of female adults. Moreover, nearly one fifth of children had elevated Hcy. Genetic factors could explain 52%, 36% and 69% of the variation in Hcy concentration among children, male adults and female adults, respectively. The MTHFR C677T variant was significantly associated with Hcy concentrations. Smokers with the TT genotype had the highest Hcy levels. Overall, our results indicate that elevated Hcy is prevalent in the children and adults in this rural Chinese population. The early identification of elevated Hcy will offer a window of opportunity for the primary prevention of CVD and metabolic syndrome. MDPI 2014-12-18 /pmc/articles/PMC4277006/ /pubmed/25529062 http://dx.doi.org/10.3390/nu6125900 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ji, Yuelong
Kong, Xiangyi
Wang, Guoying
Hong, Xiumei
Xu, Xin
Chen, Zhu
Bartell, Tami
Xu, Xiping
Tang, Genfu
Hou, Fanfan
Huo, Yong
Wang, Xiaobin
Wang, Binyan
Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan
title Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan
title_full Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan
title_fullStr Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan
title_full_unstemmed Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan
title_short Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan
title_sort distribution and determinants of plasma homocysteine levels in rural chinese twins across the lifespan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277006/
https://www.ncbi.nlm.nih.gov/pubmed/25529062
http://dx.doi.org/10.3390/nu6125900
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