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Mining CK2 in Cancer

Cancer is a leading cause of death worldwide. Cancer cells proliferate uncontrollably and, many cases, spread to other parts of the body. A protein historically involved in cancer is protein kinase CK2. CK2 is a serine-threonine kinase that has been involved in cell growth, cell proliferation and ce...

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Autores principales: Ortega, Charina E., Seidner, Yoshua, Dominguez, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277308/
https://www.ncbi.nlm.nih.gov/pubmed/25541719
http://dx.doi.org/10.1371/journal.pone.0115609
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author Ortega, Charina E.
Seidner, Yoshua
Dominguez, Isabel
author_facet Ortega, Charina E.
Seidner, Yoshua
Dominguez, Isabel
author_sort Ortega, Charina E.
collection PubMed
description Cancer is a leading cause of death worldwide. Cancer cells proliferate uncontrollably and, many cases, spread to other parts of the body. A protein historically involved in cancer is protein kinase CK2. CK2 is a serine-threonine kinase that has been involved in cell growth, cell proliferation and cell apoptosis. CK2 functions as an oncogene when overexpressed in mouse tissues, and can synergize with known oncogenes, such as ras, to induce cell transformation in cells in culture. CK2, typically the CK2α protein, is found elevated in a number of human tumors. However, we have little information on CK2α' and CK2β proteins, and scarce information on CK2 gene transcript expression. Here, we explore the expression of CK2 transcripts in primary tumor tissues using the database Oncomine in the six cancers with the highest mortality in the U.S.A. In addition, we studied the correlation between CK2 expression and overall survival using the Kaplan-Meier Plotter database in breast, ovarian, and lung cancers. We found widespread upregulation in the expression of CK2 genes in primary tumor tissues. However, we found underexpression of CK2α' transcripts in some tumors, increased CK2β transcripts in some invasive tumors, and deregulation of CK2 transcripts in some tumor precursors. There was also correlation between CK2 expression levels and patient survival. These data provides additional evidence for CK2 as a biomarker for cancer studies and as a target for cancer therapy.
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spelling pubmed-42773082014-12-31 Mining CK2 in Cancer Ortega, Charina E. Seidner, Yoshua Dominguez, Isabel PLoS One Research Article Cancer is a leading cause of death worldwide. Cancer cells proliferate uncontrollably and, many cases, spread to other parts of the body. A protein historically involved in cancer is protein kinase CK2. CK2 is a serine-threonine kinase that has been involved in cell growth, cell proliferation and cell apoptosis. CK2 functions as an oncogene when overexpressed in mouse tissues, and can synergize with known oncogenes, such as ras, to induce cell transformation in cells in culture. CK2, typically the CK2α protein, is found elevated in a number of human tumors. However, we have little information on CK2α' and CK2β proteins, and scarce information on CK2 gene transcript expression. Here, we explore the expression of CK2 transcripts in primary tumor tissues using the database Oncomine in the six cancers with the highest mortality in the U.S.A. In addition, we studied the correlation between CK2 expression and overall survival using the Kaplan-Meier Plotter database in breast, ovarian, and lung cancers. We found widespread upregulation in the expression of CK2 genes in primary tumor tissues. However, we found underexpression of CK2α' transcripts in some tumors, increased CK2β transcripts in some invasive tumors, and deregulation of CK2 transcripts in some tumor precursors. There was also correlation between CK2 expression levels and patient survival. These data provides additional evidence for CK2 as a biomarker for cancer studies and as a target for cancer therapy. Public Library of Science 2014-12-26 /pmc/articles/PMC4277308/ /pubmed/25541719 http://dx.doi.org/10.1371/journal.pone.0115609 Text en © 2014 Ortega et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ortega, Charina E.
Seidner, Yoshua
Dominguez, Isabel
Mining CK2 in Cancer
title Mining CK2 in Cancer
title_full Mining CK2 in Cancer
title_fullStr Mining CK2 in Cancer
title_full_unstemmed Mining CK2 in Cancer
title_short Mining CK2 in Cancer
title_sort mining ck2 in cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277308/
https://www.ncbi.nlm.nih.gov/pubmed/25541719
http://dx.doi.org/10.1371/journal.pone.0115609
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