PI3K/AKT/mTOR pathway activation in primary and corresponding metastatic breast tumors after adjuvant endocrine therapy

Both preclinical and clinical data suggest that activation of the PI3K/AKT/mTOR pathway in response to hormonal therapy results in acquired endocrine therapy resistance. We evaluated differences in activation of the PI3K/AKT/mTOR pathway in estrogen receptor α (ERα) positive primary and correspondin...

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Detalles Bibliográficos
Autores principales: Beelen, Karin, Hoefnagel, Laurien DC, Opdam, Mark, Wesseling, Jelle, Sanders, J, Vincent, Andrew D, van Diest, Paul J, Linn, Sabine C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277331/
https://www.ncbi.nlm.nih.gov/pubmed/24501006
http://dx.doi.org/10.1002/ijc.28769

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