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Adaptive Combination of P-Values for Family-Based Association Testing with Sequence Data
Family-based study design will play a key role in identifying rare causal variants, because rare causal variants can be enriched in families with multiple affected subjects. Furthermore, different from population-based studies, family studies are robust to bias induced by population substructure. It...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277421/ https://www.ncbi.nlm.nih.gov/pubmed/25541952 http://dx.doi.org/10.1371/journal.pone.0115971 |