In-silico Investigation of Tubulin Binding Modes of a Series of Novel Antiproliferative Spiroisoxazoline Compounds Using Docking Studies

Interference with microtubule polymerization results in cell cycle arrest leading to cell death. Colchicine is a well-known microtubule polymerization inhibitor which does so by binding to a specific site on tubulin. A set of 3', 4'-bis (substituted phenyl)-4'H-spiro [indene-2, 5'...

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Detalles Bibliográficos
Autores principales: Abolhasani, Hoda, Zarghi, Afshin, Hamzeh-Mivehroud, Maryam, Alizadeh, Ali Akbar, Shahbazi Mojarrad, Javid, Dastmalchi, Siavoush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277627/
https://www.ncbi.nlm.nih.gov/pubmed/25561920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277627/
https://www.ncbi.nlm.nih.gov/pubmed/25561920

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