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In-silico Investigation of Tubulin Binding Modes of a Series of Novel Antiproliferative Spiroisoxazoline Compounds Using Docking Studies

Interference with microtubule polymerization results in cell cycle arrest leading to cell death. Colchicine is a well-known microtubule polymerization inhibitor which does so by binding to a specific site on tubulin. A set of 3', 4'-bis (substituted phenyl)-4'H-spiro [indene-2, 5'...

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Detalles Bibliográficos
Autores principales:	Abolhasani, Hoda, Zarghi, Afshin, Hamzeh-Mivehroud, Maryam, Alizadeh, Ali Akbar, Shahbazi Mojarrad, Javid, Dastmalchi, Siavoush
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shaheed Beheshti University of Medical Sciences 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277627/ https://www.ncbi.nlm.nih.gov/pubmed/25561920

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