Ligand-Controlled, Tunable Silver-Catalyzed C–H Amination

[Image: see text] The development of readily tunable and regioselective C–H functionalization reactions that operate solely through catalyst control remains a challenge in modern organic synthesis. Herein, we report that simple silver catalysts supported by common nitrogenated ligands can be used to...

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Autores principales: Alderson, Juliet M., Phelps, Alicia M., Scamp, Ryan J., Dolan, Nicholas S., Schomaker, Jennifer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277762/
https://www.ncbi.nlm.nih.gov/pubmed/25386769
http://dx.doi.org/10.1021/ja5094309
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author Alderson, Juliet M.
Phelps, Alicia M.
Scamp, Ryan J.
Dolan, Nicholas S.
Schomaker, Jennifer M.
author_facet Alderson, Juliet M.
Phelps, Alicia M.
Scamp, Ryan J.
Dolan, Nicholas S.
Schomaker, Jennifer M.
author_sort Alderson, Juliet M.
collection PubMed
description [Image: see text] The development of readily tunable and regioselective C–H functionalization reactions that operate solely through catalyst control remains a challenge in modern organic synthesis. Herein, we report that simple silver catalysts supported by common nitrogenated ligands can be used to tune a nitrene transfer reaction between two different types of C–H bonds. The results reported herein represent the first example of ligand-controlled and site-selective silver-promoted C–H amination.
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spelling pubmed-42777622015-11-11 Ligand-Controlled, Tunable Silver-Catalyzed C–H Amination Alderson, Juliet M. Phelps, Alicia M. Scamp, Ryan J. Dolan, Nicholas S. Schomaker, Jennifer M. J Am Chem Soc [Image: see text] The development of readily tunable and regioselective C–H functionalization reactions that operate solely through catalyst control remains a challenge in modern organic synthesis. Herein, we report that simple silver catalysts supported by common nitrogenated ligands can be used to tune a nitrene transfer reaction between two different types of C–H bonds. The results reported herein represent the first example of ligand-controlled and site-selective silver-promoted C–H amination. American Chemical Society 2014-11-11 2014-12-03 /pmc/articles/PMC4277762/ /pubmed/25386769 http://dx.doi.org/10.1021/ja5094309 Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Alderson, Juliet M.
Phelps, Alicia M.
Scamp, Ryan J.
Dolan, Nicholas S.
Schomaker, Jennifer M.
Ligand-Controlled, Tunable Silver-Catalyzed C–H Amination
title Ligand-Controlled, Tunable Silver-Catalyzed C–H Amination
title_full Ligand-Controlled, Tunable Silver-Catalyzed C–H Amination
title_fullStr Ligand-Controlled, Tunable Silver-Catalyzed C–H Amination
title_full_unstemmed Ligand-Controlled, Tunable Silver-Catalyzed C–H Amination
title_short Ligand-Controlled, Tunable Silver-Catalyzed C–H Amination
title_sort ligand-controlled, tunable silver-catalyzed c–h amination
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277762/
https://www.ncbi.nlm.nih.gov/pubmed/25386769
http://dx.doi.org/10.1021/ja5094309
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AT phelpsaliciam ligandcontrolledtunablesilvercatalyzedchamination
AT scampryanj ligandcontrolledtunablesilvercatalyzedchamination
AT dolannicholass ligandcontrolledtunablesilvercatalyzedchamination
AT schomakerjenniferm ligandcontrolledtunablesilvercatalyzedchamination

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