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Biomimetic ceramics for periodontal regeneration in infrabony defects: A systematic review

Biomimetic materials are widely used in the treatment of osseous defects as an alternative to autogenous bone graft. The aim of this article was to review the literature and compare the quality of published articles on biomimetic ceramic material used for periodontal regeneration in the treatment of...

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Autores principales: Rai, Jasuma Jagdish, Kalantharakath, Thanveer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278107/
https://www.ncbi.nlm.nih.gov/pubmed/25558455
http://dx.doi.org/10.4103/2231-0762.146207
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author Rai, Jasuma Jagdish
Kalantharakath, Thanveer
author_facet Rai, Jasuma Jagdish
Kalantharakath, Thanveer
author_sort Rai, Jasuma Jagdish
collection PubMed
description Biomimetic materials are widely used in the treatment of osseous defects as an alternative to autogenous bone graft. The aim of this article was to review the literature and compare the quality of published articles on biomimetic ceramic material used for periodontal regeneration in the treatment of infrabony defects and to discuss the future direction of research. The bibliographic databases PubMed, Ebsco, and Google Scholar were searched from January 2000 to March 2014 for randomized control trials in which biomimetic ceramic graft material was compared with open flap debridement or in combination with any other regenerative material. To avoid the variability of the search terms, the thesaurus Mesh was used. The primary outcome variable assessed was clinical attachment level (CAL). The screening of eligible studies, assessment of the methodological quality of the trials, and data extraction were performed by two observers independently. Twenty-six articles were identified and included in this systematic review. The primary outcome was CAL. Out of the 26 studies, 24 showed more than 2 mm of CAL gain. The difference in CAL change between test and control groups varied from 1.2 mm to 5.88 mm with respect to different biomaterials/biomimetic materials, which was clinically and statistically significant. Meta-analysis was not done due to heterogeneity in results between studies. Overall, biomaterials were found to be more effective than open flap debridement in improving the attachment levels in intraosseous defects. Future research should aim at increasing the osteoinductive capacity of these biomimetic graft materials.
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spelling pubmed-42781072015-01-02 Biomimetic ceramics for periodontal regeneration in infrabony defects: A systematic review Rai, Jasuma Jagdish Kalantharakath, Thanveer J Int Soc Prev Community Dent Review Article Biomimetic materials are widely used in the treatment of osseous defects as an alternative to autogenous bone graft. The aim of this article was to review the literature and compare the quality of published articles on biomimetic ceramic material used for periodontal regeneration in the treatment of infrabony defects and to discuss the future direction of research. The bibliographic databases PubMed, Ebsco, and Google Scholar were searched from January 2000 to March 2014 for randomized control trials in which biomimetic ceramic graft material was compared with open flap debridement or in combination with any other regenerative material. To avoid the variability of the search terms, the thesaurus Mesh was used. The primary outcome variable assessed was clinical attachment level (CAL). The screening of eligible studies, assessment of the methodological quality of the trials, and data extraction were performed by two observers independently. Twenty-six articles were identified and included in this systematic review. The primary outcome was CAL. Out of the 26 studies, 24 showed more than 2 mm of CAL gain. The difference in CAL change between test and control groups varied from 1.2 mm to 5.88 mm with respect to different biomaterials/biomimetic materials, which was clinically and statistically significant. Meta-analysis was not done due to heterogeneity in results between studies. Overall, biomaterials were found to be more effective than open flap debridement in improving the attachment levels in intraosseous defects. Future research should aim at increasing the osteoinductive capacity of these biomimetic graft materials. Medknow Publications & Media Pvt Ltd 2014-12 /pmc/articles/PMC4278107/ /pubmed/25558455 http://dx.doi.org/10.4103/2231-0762.146207 Text en Copyright: © Journal of International Society of Preventive and Community Dentistry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rai, Jasuma Jagdish
Kalantharakath, Thanveer
Biomimetic ceramics for periodontal regeneration in infrabony defects: A systematic review
title Biomimetic ceramics for periodontal regeneration in infrabony defects: A systematic review
title_full Biomimetic ceramics for periodontal regeneration in infrabony defects: A systematic review
title_fullStr Biomimetic ceramics for periodontal regeneration in infrabony defects: A systematic review
title_full_unstemmed Biomimetic ceramics for periodontal regeneration in infrabony defects: A systematic review
title_short Biomimetic ceramics for periodontal regeneration in infrabony defects: A systematic review
title_sort biomimetic ceramics for periodontal regeneration in infrabony defects: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278107/
https://www.ncbi.nlm.nih.gov/pubmed/25558455
http://dx.doi.org/10.4103/2231-0762.146207
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