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Hydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel

Large-conductance Ca(2+)- and voltage-activated K(+) channel (BK) open probability is enhanced by depolarization, increasing Ca(2+) concentration, or both. These stimuli activate modular voltage and Ca(2+) sensors that are allosterically coupled to channel gating. Here, we report a point mutation of...

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Detalles Bibliográficos
Autores principales:	Carrasquel-Ursulaez, Willy, Contreras, Gustavo F., Sepúlveda, Romina V., Aguayo, Daniel, González-Nilo, Fernando, González, Carlos, Latorre, Ramón
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278184/ https://www.ncbi.nlm.nih.gov/pubmed/25548136 http://dx.doi.org/10.1085/jgp.201411194

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