Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021

Eight new chromones, engyodontiumones A–H (1–8), and three new phenol derivatives (9–11) together with eight known polyketides (12–19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16...

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Autores principales: Yao, Qifeng, Wang, Jie, Zhang, Xiaoyong, Nong, Xuhua, Xu, Xinya, Qi, Shuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278208/
https://www.ncbi.nlm.nih.gov/pubmed/25501793
http://dx.doi.org/10.3390/md12125902
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author Yao, Qifeng
Wang, Jie
Zhang, Xiaoyong
Nong, Xuhua
Xu, Xinya
Qi, Shuhua
author_facet Yao, Qifeng
Wang, Jie
Zhang, Xiaoyong
Nong, Xuhua
Xu, Xinya
Qi, Shuhua
author_sort Yao, Qifeng
collection PubMed
description Eight new chromones, engyodontiumones A–H (1–8), and three new phenol derivatives (9–11) together with eight known polyketides (12–19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16 showed significant selective cytotoxicity against human histiocytic lymphoma U937 cell line with IC(50) values of 4.9 and 8.8 μM, respectively. In addition, this is the first time to report that 8, 15 and 16 had mild antibacterial activity against Escherichia coli and Bacillus subtilis, and 15 showed potent antilarval activity against barnacle Balanus amphitrite larval settlement.
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spelling pubmed-42782082015-01-08 Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021 Yao, Qifeng Wang, Jie Zhang, Xiaoyong Nong, Xuhua Xu, Xinya Qi, Shuhua Mar Drugs Article Eight new chromones, engyodontiumones A–H (1–8), and three new phenol derivatives (9–11) together with eight known polyketides (12–19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16 showed significant selective cytotoxicity against human histiocytic lymphoma U937 cell line with IC(50) values of 4.9 and 8.8 μM, respectively. In addition, this is the first time to report that 8, 15 and 16 had mild antibacterial activity against Escherichia coli and Bacillus subtilis, and 15 showed potent antilarval activity against barnacle Balanus amphitrite larval settlement. MDPI 2014-12-09 /pmc/articles/PMC4278208/ /pubmed/25501793 http://dx.doi.org/10.3390/md12125902 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yao, Qifeng
Wang, Jie
Zhang, Xiaoyong
Nong, Xuhua
Xu, Xinya
Qi, Shuhua
Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021
title Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021
title_full Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021
title_fullStr Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021
title_full_unstemmed Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021
title_short Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021
title_sort cytotoxic polyketides from the deep-sea-derived fungus engyodontium album dffscs021
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278208/
https://www.ncbi.nlm.nih.gov/pubmed/25501793
http://dx.doi.org/10.3390/md12125902
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