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Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum
Seven new 6,6-spiroketals, sargassopenillines A–G (1–7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were ass...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278210/ https://www.ncbi.nlm.nih.gov/pubmed/25501795 http://dx.doi.org/10.3390/md12125930 |
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author | Zhuravleva, Olesya I. Sobolevskaya, Maria P. Afiyatullov, Shamil Sh. Kirichuk, Natalya N. Denisenko, Vladimir A. Dmitrenok, Pavel S. Yurchenko, Ekaterina A. Dyshlovoy, Sergey A. |
author_facet | Zhuravleva, Olesya I. Sobolevskaya, Maria P. Afiyatullov, Shamil Sh. Kirichuk, Natalya N. Denisenko, Vladimir A. Dmitrenok, Pavel S. Yurchenko, Ekaterina A. Dyshlovoy, Sergey A. |
author_sort | Zhuravleva, Olesya I. |
collection | PubMed |
description | Seven new 6,6-spiroketals, sargassopenillines A–G (1–7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher’s method and by CD data. Sargassopenilline C (3) inhibited the transcriptional activity of the oncogenic nuclear factor AP-1 with an IC(50) value of 15 µM. |
format | Online Article Text |
id | pubmed-4278210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42782102015-01-08 Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum Zhuravleva, Olesya I. Sobolevskaya, Maria P. Afiyatullov, Shamil Sh. Kirichuk, Natalya N. Denisenko, Vladimir A. Dmitrenok, Pavel S. Yurchenko, Ekaterina A. Dyshlovoy, Sergey A. Mar Drugs Article Seven new 6,6-spiroketals, sargassopenillines A–G (1–7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher’s method and by CD data. Sargassopenilline C (3) inhibited the transcriptional activity of the oncogenic nuclear factor AP-1 with an IC(50) value of 15 µM. MDPI 2014-12-09 /pmc/articles/PMC4278210/ /pubmed/25501795 http://dx.doi.org/10.3390/md12125930 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhuravleva, Olesya I. Sobolevskaya, Maria P. Afiyatullov, Shamil Sh. Kirichuk, Natalya N. Denisenko, Vladimir A. Dmitrenok, Pavel S. Yurchenko, Ekaterina A. Dyshlovoy, Sergey A. Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum |
title | Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum |
title_full | Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum |
title_fullStr | Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum |
title_full_unstemmed | Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum |
title_short | Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum |
title_sort | sargassopenillines a–g, 6,6-spiroketals from the alga-derived fungi penicillium thomii and penicillium lividum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278210/ https://www.ncbi.nlm.nih.gov/pubmed/25501795 http://dx.doi.org/10.3390/md12125930 |
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