Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum

Seven new 6,6-spiroketals, sargassopenillines A–G (1–7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were ass...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhuravleva, Olesya I., Sobolevskaya, Maria P., Afiyatullov, Shamil Sh., Kirichuk, Natalya N., Denisenko, Vladimir A., Dmitrenok, Pavel S., Yurchenko, Ekaterina A., Dyshlovoy, Sergey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278210/
https://www.ncbi.nlm.nih.gov/pubmed/25501795
http://dx.doi.org/10.3390/md12125930
_version_ 1782350484711931904
author Zhuravleva, Olesya I.
Sobolevskaya, Maria P.
Afiyatullov, Shamil Sh.
Kirichuk, Natalya N.
Denisenko, Vladimir A.
Dmitrenok, Pavel S.
Yurchenko, Ekaterina A.
Dyshlovoy, Sergey A.
author_facet Zhuravleva, Olesya I.
Sobolevskaya, Maria P.
Afiyatullov, Shamil Sh.
Kirichuk, Natalya N.
Denisenko, Vladimir A.
Dmitrenok, Pavel S.
Yurchenko, Ekaterina A.
Dyshlovoy, Sergey A.
author_sort Zhuravleva, Olesya I.
collection PubMed
description Seven new 6,6-spiroketals, sargassopenillines A–G (1–7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher’s method and by CD data. Sargassopenilline C (3) inhibited the transcriptional activity of the oncogenic nuclear factor AP-1 with an IC(50) value of 15 µM.
format Online
Article
Text
id pubmed-4278210
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-42782102015-01-08 Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum Zhuravleva, Olesya I. Sobolevskaya, Maria P. Afiyatullov, Shamil Sh. Kirichuk, Natalya N. Denisenko, Vladimir A. Dmitrenok, Pavel S. Yurchenko, Ekaterina A. Dyshlovoy, Sergey A. Mar Drugs Article Seven new 6,6-spiroketals, sargassopenillines A–G (1–7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher’s method and by CD data. Sargassopenilline C (3) inhibited the transcriptional activity of the oncogenic nuclear factor AP-1 with an IC(50) value of 15 µM. MDPI 2014-12-09 /pmc/articles/PMC4278210/ /pubmed/25501795 http://dx.doi.org/10.3390/md12125930 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhuravleva, Olesya I.
Sobolevskaya, Maria P.
Afiyatullov, Shamil Sh.
Kirichuk, Natalya N.
Denisenko, Vladimir A.
Dmitrenok, Pavel S.
Yurchenko, Ekaterina A.
Dyshlovoy, Sergey A.
Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum
title Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum
title_full Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum
title_fullStr Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum
title_full_unstemmed Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum
title_short Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum
title_sort sargassopenillines a–g, 6,6-spiroketals from the alga-derived fungi penicillium thomii and penicillium lividum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278210/
https://www.ncbi.nlm.nih.gov/pubmed/25501795
http://dx.doi.org/10.3390/md12125930
work_keys_str_mv AT zhuravlevaolesyai sargassopenillinesag66spiroketalsfromthealgaderivedfungipenicilliumthomiiandpenicilliumlividum
AT sobolevskayamariap sargassopenillinesag66spiroketalsfromthealgaderivedfungipenicilliumthomiiandpenicilliumlividum
AT afiyatullovshamilsh sargassopenillinesag66spiroketalsfromthealgaderivedfungipenicilliumthomiiandpenicilliumlividum
AT kirichuknatalyan sargassopenillinesag66spiroketalsfromthealgaderivedfungipenicilliumthomiiandpenicilliumlividum
AT denisenkovladimira sargassopenillinesag66spiroketalsfromthealgaderivedfungipenicilliumthomiiandpenicilliumlividum
AT dmitrenokpavels sargassopenillinesag66spiroketalsfromthealgaderivedfungipenicilliumthomiiandpenicilliumlividum
AT yurchenkoekaterinaa sargassopenillinesag66spiroketalsfromthealgaderivedfungipenicilliumthomiiandpenicilliumlividum
AT dyshlovoysergeya sargassopenillinesag66spiroketalsfromthealgaderivedfungipenicilliumthomiiandpenicilliumlividum

Ejemplares similares