Three New Asperentin Derivatives from the Algicolous Fungus Aspergillus sp. F00785

Three new asperentin-type compounds, 6-O-α-d-ribosylasperentin (1) and 6-O-α-d-ribosyl-8-O-methylasperentin (2) and 5-hydroxyl-6-O-methylasperentin (3), along with asperentin (4) and its known analogues (5–9), were isolated from a halotolerant Aspergillus sp. strain F00785, an endotrophic fungus fro...

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Autores principales: Tang, Qian, Guo, Kai, Li, Xiao-Yang, Zheng, Xiu-Ying, Kong, Xiang-Jian, Zheng, Zhong-Hui, Xu, Qing-Yan, Deng, Xianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278214/
https://www.ncbi.nlm.nih.gov/pubmed/25517217
http://dx.doi.org/10.3390/md12125993
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author Tang, Qian
Guo, Kai
Li, Xiao-Yang
Zheng, Xiu-Ying
Kong, Xiang-Jian
Zheng, Zhong-Hui
Xu, Qing-Yan
Deng, Xianming
author_facet Tang, Qian
Guo, Kai
Li, Xiao-Yang
Zheng, Xiu-Ying
Kong, Xiang-Jian
Zheng, Zhong-Hui
Xu, Qing-Yan
Deng, Xianming
author_sort Tang, Qian
collection PubMed
description Three new asperentin-type compounds, 6-O-α-d-ribosylasperentin (1) and 6-O-α-d-ribosyl-8-O-methylasperentin (2) and 5-hydroxyl-6-O-methylasperentin (3), along with asperentin (4) and its known analogues (5–9), were isolated from a halotolerant Aspergillus sp. strain F00785, an endotrophic fungus from marine alga. Their structures were determined using extensive NMR and HRESIMS spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of compound 9. Compound 4 exhibited highly potent inhibitory activity against crop pathogens, Colletotrichum gleosporioides Penz. and Colletotrichum gleosporioides (Penz.) Sacc.
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spelling pubmed-42782142015-01-08 Three New Asperentin Derivatives from the Algicolous Fungus Aspergillus sp. F00785 Tang, Qian Guo, Kai Li, Xiao-Yang Zheng, Xiu-Ying Kong, Xiang-Jian Zheng, Zhong-Hui Xu, Qing-Yan Deng, Xianming Mar Drugs Article Three new asperentin-type compounds, 6-O-α-d-ribosylasperentin (1) and 6-O-α-d-ribosyl-8-O-methylasperentin (2) and 5-hydroxyl-6-O-methylasperentin (3), along with asperentin (4) and its known analogues (5–9), were isolated from a halotolerant Aspergillus sp. strain F00785, an endotrophic fungus from marine alga. Their structures were determined using extensive NMR and HRESIMS spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of compound 9. Compound 4 exhibited highly potent inhibitory activity against crop pathogens, Colletotrichum gleosporioides Penz. and Colletotrichum gleosporioides (Penz.) Sacc. MDPI 2014-12-15 /pmc/articles/PMC4278214/ /pubmed/25517217 http://dx.doi.org/10.3390/md12125993 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tang, Qian
Guo, Kai
Li, Xiao-Yang
Zheng, Xiu-Ying
Kong, Xiang-Jian
Zheng, Zhong-Hui
Xu, Qing-Yan
Deng, Xianming
Three New Asperentin Derivatives from the Algicolous Fungus Aspergillus sp. F00785
title Three New Asperentin Derivatives from the Algicolous Fungus Aspergillus sp. F00785
title_full Three New Asperentin Derivatives from the Algicolous Fungus Aspergillus sp. F00785
title_fullStr Three New Asperentin Derivatives from the Algicolous Fungus Aspergillus sp. F00785
title_full_unstemmed Three New Asperentin Derivatives from the Algicolous Fungus Aspergillus sp. F00785
title_short Three New Asperentin Derivatives from the Algicolous Fungus Aspergillus sp. F00785
title_sort three new asperentin derivatives from the algicolous fungus aspergillus sp. f00785
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278214/
https://www.ncbi.nlm.nih.gov/pubmed/25517217
http://dx.doi.org/10.3390/md12125993
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