Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum

Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher...

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Autores principales: Cheng, Shi-Yie, Wang, Shang-Kwei, Duh, Chang-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278217/
https://www.ncbi.nlm.nih.gov/pubmed/25522315
http://dx.doi.org/10.3390/md12126028
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author Cheng, Shi-Yie
Wang, Shang-Kwei
Duh, Chang-Yih
author_facet Cheng, Shi-Yie
Wang, Shang-Kwei
Duh, Chang-Yih
author_sort Cheng, Shi-Yie
collection PubMed
description Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher’s acylation. Secocrassumol differs from previously known marine seco-cembranoid in that it possesses an unprecedented skeleton functionalized at C11-C12 bond cleavage. Secocrassumol showed antiviral activity against human cytomegalovirus (HCMV) with an IC(50) value of 5.0 μg/mL.
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spelling pubmed-42782172015-01-08 Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum Cheng, Shi-Yie Wang, Shang-Kwei Duh, Chang-Yih Mar Drugs Article Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher’s acylation. Secocrassumol differs from previously known marine seco-cembranoid in that it possesses an unprecedented skeleton functionalized at C11-C12 bond cleavage. Secocrassumol showed antiviral activity against human cytomegalovirus (HCMV) with an IC(50) value of 5.0 μg/mL. MDPI 2014-12-17 /pmc/articles/PMC4278217/ /pubmed/25522315 http://dx.doi.org/10.3390/md12126028 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Shi-Yie
Wang, Shang-Kwei
Duh, Chang-Yih
Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum
title Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum
title_full Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum
title_fullStr Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum
title_full_unstemmed Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum
title_short Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum
title_sort secocrassumol, a seco-cembranoid from the dongsha atoll soft coral lobophytum crassum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278217/
https://www.ncbi.nlm.nih.gov/pubmed/25522315
http://dx.doi.org/10.3390/md12126028
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AT duhchangyih secocrassumolasecocembranoidfromthedongshaatollsoftcorallobophytumcrassum

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