Briarane Diterpenoids from the Gorgonian Dichotella gemmacea

Seven new briarane diterpenoids, gemmacolides AS-AY (1–7), were isolated together with ten known analogues (8–17) from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of spectroscopic data and comparison with reported da...

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Detalles Bibliográficos
Autores principales: La, Ming-Ping, Li, Jiao, Li, Cui, Tang, Hua, Liu, Bao-Shu, Sun, Peng, Zhuang, Chun-Lin, Li, Tie-Jun, Zhang, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278224/
https://www.ncbi.nlm.nih.gov/pubmed/25528959
http://dx.doi.org/10.3390/md12126178
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author La, Ming-Ping
Li, Jiao
Li, Cui
Tang, Hua
Liu, Bao-Shu
Sun, Peng
Zhuang, Chun-Lin
Li, Tie-Jun
Zhang, Wen
author_facet La, Ming-Ping
Li, Jiao
Li, Cui
Tang, Hua
Liu, Bao-Shu
Sun, Peng
Zhuang, Chun-Lin
Li, Tie-Jun
Zhang, Wen
author_sort La, Ming-Ping
collection PubMed
description Seven new briarane diterpenoids, gemmacolides AS-AY (1–7), were isolated together with ten known analogues (8–17) from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of spectroscopic data and comparison with reported data. The absolute configuration of compounds was determined based on electronic circular dichroism (ECD) experiments and genetic correlations as well. Compounds 15 and 16 were reported for the first time for the gorgonian. In the preliminary in vitro bioassays, compound 5 showed potential growth inhibitory activity against MG63 cells.
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spelling pubmed-42782242015-01-08 Briarane Diterpenoids from the Gorgonian Dichotella gemmacea La, Ming-Ping Li, Jiao Li, Cui Tang, Hua Liu, Bao-Shu Sun, Peng Zhuang, Chun-Lin Li, Tie-Jun Zhang, Wen Mar Drugs Article Seven new briarane diterpenoids, gemmacolides AS-AY (1–7), were isolated together with ten known analogues (8–17) from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of spectroscopic data and comparison with reported data. The absolute configuration of compounds was determined based on electronic circular dichroism (ECD) experiments and genetic correlations as well. Compounds 15 and 16 were reported for the first time for the gorgonian. In the preliminary in vitro bioassays, compound 5 showed potential growth inhibitory activity against MG63 cells. MDPI 2014-12-18 /pmc/articles/PMC4278224/ /pubmed/25528959 http://dx.doi.org/10.3390/md12126178 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
La, Ming-Ping
Li, Jiao
Li, Cui
Tang, Hua
Liu, Bao-Shu
Sun, Peng
Zhuang, Chun-Lin
Li, Tie-Jun
Zhang, Wen
Briarane Diterpenoids from the Gorgonian Dichotella gemmacea
title Briarane Diterpenoids from the Gorgonian Dichotella gemmacea
title_full Briarane Diterpenoids from the Gorgonian Dichotella gemmacea
title_fullStr Briarane Diterpenoids from the Gorgonian Dichotella gemmacea
title_full_unstemmed Briarane Diterpenoids from the Gorgonian Dichotella gemmacea
title_short Briarane Diterpenoids from the Gorgonian Dichotella gemmacea
title_sort briarane diterpenoids from the gorgonian dichotella gemmacea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278224/
https://www.ncbi.nlm.nih.gov/pubmed/25528959
http://dx.doi.org/10.3390/md12126178
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