CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation

CEP2 (CDC42EP2) is a member of the CDC42 subfamily that belongs to the Rho family. The Rho family plays an important role in a variety of cellular processes including skeletal myogenesis. Here, we find the expression of CEP2 increased significantly during C2C12 myogenesis. Overexpression of CEP2 cou...

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Autores principales: Wu, Ming, Yang, Gongshe, Chen, Yaosheng, Zhou, Xingyu, Chen, Hu, Li, Mingsen, Yu, Kaifan, Zhang, Xumeng, Xie, Shuihua, Zhang, Ying, Chu, Guiyan, Mo, Delin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278259/
https://www.ncbi.nlm.nih.gov/pubmed/25552934
http://dx.doi.org/10.7150/ijbs.8621
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author Wu, Ming
Yang, Gongshe
Chen, Yaosheng
Zhou, Xingyu
Chen, Hu
Li, Mingsen
Yu, Kaifan
Zhang, Xumeng
Xie, Shuihua
Zhang, Ying
Chu, Guiyan
Mo, Delin
author_facet Wu, Ming
Yang, Gongshe
Chen, Yaosheng
Zhou, Xingyu
Chen, Hu
Li, Mingsen
Yu, Kaifan
Zhang, Xumeng
Xie, Shuihua
Zhang, Ying
Chu, Guiyan
Mo, Delin
author_sort Wu, Ming
collection PubMed
description CEP2 (CDC42EP2) is a member of the CDC42 subfamily that belongs to the Rho family. The Rho family plays an important role in a variety of cellular processes including skeletal myogenesis. Here, we find the expression of CEP2 increased significantly during C2C12 myogenesis. Overexpression of CEP2 could attenuate myoblast differentiation, while knockdown of CEP2 by siRNA results in enhancing myogenesis. Furthermore, we demonstrate for the first time that CEP2 attenuates myoblast differentiation via suppression of muscle regulatory factors (MRFs) rather than influencing myoblast proliferation. These results indicate that CEP2 acts as a repressor during myogenesis, which provides new insights into the role of CEP2 in muscle development.
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spelling pubmed-42782592015-01-01 CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation Wu, Ming Yang, Gongshe Chen, Yaosheng Zhou, Xingyu Chen, Hu Li, Mingsen Yu, Kaifan Zhang, Xumeng Xie, Shuihua Zhang, Ying Chu, Guiyan Mo, Delin Int J Biol Sci Research Paper CEP2 (CDC42EP2) is a member of the CDC42 subfamily that belongs to the Rho family. The Rho family plays an important role in a variety of cellular processes including skeletal myogenesis. Here, we find the expression of CEP2 increased significantly during C2C12 myogenesis. Overexpression of CEP2 could attenuate myoblast differentiation, while knockdown of CEP2 by siRNA results in enhancing myogenesis. Furthermore, we demonstrate for the first time that CEP2 attenuates myoblast differentiation via suppression of muscle regulatory factors (MRFs) rather than influencing myoblast proliferation. These results indicate that CEP2 acts as a repressor during myogenesis, which provides new insights into the role of CEP2 in muscle development. Ivyspring International Publisher 2015-01-01 /pmc/articles/PMC4278259/ /pubmed/25552934 http://dx.doi.org/10.7150/ijbs.8621 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
Wu, Ming
Yang, Gongshe
Chen, Yaosheng
Zhou, Xingyu
Chen, Hu
Li, Mingsen
Yu, Kaifan
Zhang, Xumeng
Xie, Shuihua
Zhang, Ying
Chu, Guiyan
Mo, Delin
CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation
title CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation
title_full CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation
title_fullStr CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation
title_full_unstemmed CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation
title_short CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation
title_sort cep2 attenuates myoblast differentiation but does not affect proliferation
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278259/
https://www.ncbi.nlm.nih.gov/pubmed/25552934
http://dx.doi.org/10.7150/ijbs.8621
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