Cytotoxicity of RNase Sa to the acute myeloid leukemia Kasumi-1 cells depends on the net charge

The majority of known cytotoxic RNases are basic proteins which destroy intracellular RNA. Cationization of RNases is considered to be an effective strategy for strengthening their antitumor properties. We constructed a set of RNase Sa variants consisting of charge reversal mutants, charge neutraliz...

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Detalles Bibliográficos
Autores principales: Mitkevich, Vladimir A., Burnysheva, Ksenia M., Ilinskaya, Olga N., Pace, C. Nick, Makarov, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278273/
https://www.ncbi.nlm.nih.gov/pubmed/25594000

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