Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor

Tumor hypoxia, a feature of many solid tumors including ovarian cancer, is associated with resistance to therapies. We previously demonstrated that hypoxic exposure results in increased expression of phosphorylated signal transducer and activator of transcription 3 (pSTAT3). We hypothesized the acti...

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Detalles Bibliográficos
Autores principales: McCann, Georgia A., Naidu, Shan, Rath, Kellie S., Bid, Hemant K., Tierney, Brent J., Suarez, Adrian, Varadharaj, Saradhadevi, Zhang, Jianying, Hideg, Kálmán, Houghton, Peter, Kuppusamy, Periannan, Cohn, David E., Selvendiran, Karuppaiyah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278289/
https://www.ncbi.nlm.nih.gov/pubmed/25594014

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