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PICT1 expression is a poor prognostic factor in non-small cell lung cancer
PICT1 is a key regulator of the MDM2–TP53 pathway. High mRNA expression levels of PICT1 are associated with poor prognosis in several cancers with wild-type TP53. In this study, we identified the PICT1 protein expression profile in non-small cell lung cancer (NSCLC) with wild-type TP53 in the nucleo...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278310/ https://www.ncbi.nlm.nih.gov/pubmed/25594032 |
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author | Okamura, Kyoko Takayama, Koichi Kawahara, Kohichi Harada, Taishi Nishio, Miki Otsubo, Kohei Ijichi, Kayo Kohno, Mikihiro Iwama, Eiji Fujii, Akiko Ota, Keiichi Koga, Takaomi Okamoto, Tatsuro Suzuki, Akira Nakanishi, Yoichi |
author_facet | Okamura, Kyoko Takayama, Koichi Kawahara, Kohichi Harada, Taishi Nishio, Miki Otsubo, Kohei Ijichi, Kayo Kohno, Mikihiro Iwama, Eiji Fujii, Akiko Ota, Keiichi Koga, Takaomi Okamoto, Tatsuro Suzuki, Akira Nakanishi, Yoichi |
author_sort | Okamura, Kyoko |
collection | PubMed |
description | PICT1 is a key regulator of the MDM2–TP53 pathway. High mRNA expression levels of PICT1 are associated with poor prognosis in several cancers with wild-type TP53. In this study, we identified the PICT1 protein expression profile in non-small cell lung cancer (NSCLC) with wild-type TP53 in the nucleolus and cytoplasm, and revealed the relationship between PICT1 expression and patient clinicopathological factors. PICT1 expression in the tumor cells of 96 NSCLC patients with wild-type TP53 was evaluated by immunohistochemistry. Forty-three of 96 (44.8%) NSCLC samples were positive for nucleolar PICT1, while 40/96 (41.7%) NSCLC samples were positive for cytoplasmic PICT1. There was no correlation between nucleolar PICT1 expression and clinicopathological factors. However, cytoplasmic PICT1 expression was significantly correlated with sex, smoking history, differentiation, lymphatic invasion and pathological stage. In multivariate analysis, lymphatic invasion was significantly associated with cytoplasmic PICT1 expression (hazard ratio: 5.02, P = 0.026). We scrutinized PICT1 expression in samples of NSCLC with wild-type TP53, and showed a correlation between cytoplasmic PICT1 expression and several clinicopathological factors in these patients. Our results indicate that cytoplasmic PICT1 expression is a poor prognostic factor and is associated with tumor progression via lymphatic invasion in these patients. |
format | Online Article Text |
id | pubmed-4278310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-42783102015-01-15 PICT1 expression is a poor prognostic factor in non-small cell lung cancer Okamura, Kyoko Takayama, Koichi Kawahara, Kohichi Harada, Taishi Nishio, Miki Otsubo, Kohei Ijichi, Kayo Kohno, Mikihiro Iwama, Eiji Fujii, Akiko Ota, Keiichi Koga, Takaomi Okamoto, Tatsuro Suzuki, Akira Nakanishi, Yoichi Oncoscience Research Paper PICT1 is a key regulator of the MDM2–TP53 pathway. High mRNA expression levels of PICT1 are associated with poor prognosis in several cancers with wild-type TP53. In this study, we identified the PICT1 protein expression profile in non-small cell lung cancer (NSCLC) with wild-type TP53 in the nucleolus and cytoplasm, and revealed the relationship between PICT1 expression and patient clinicopathological factors. PICT1 expression in the tumor cells of 96 NSCLC patients with wild-type TP53 was evaluated by immunohistochemistry. Forty-three of 96 (44.8%) NSCLC samples were positive for nucleolar PICT1, while 40/96 (41.7%) NSCLC samples were positive for cytoplasmic PICT1. There was no correlation between nucleolar PICT1 expression and clinicopathological factors. However, cytoplasmic PICT1 expression was significantly correlated with sex, smoking history, differentiation, lymphatic invasion and pathological stage. In multivariate analysis, lymphatic invasion was significantly associated with cytoplasmic PICT1 expression (hazard ratio: 5.02, P = 0.026). We scrutinized PICT1 expression in samples of NSCLC with wild-type TP53, and showed a correlation between cytoplasmic PICT1 expression and several clinicopathological factors in these patients. Our results indicate that cytoplasmic PICT1 expression is a poor prognostic factor and is associated with tumor progression via lymphatic invasion in these patients. Impact Journals LLC 2014-05-25 /pmc/articles/PMC4278310/ /pubmed/25594032 Text en © 2014 Okamura et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Okamura, Kyoko Takayama, Koichi Kawahara, Kohichi Harada, Taishi Nishio, Miki Otsubo, Kohei Ijichi, Kayo Kohno, Mikihiro Iwama, Eiji Fujii, Akiko Ota, Keiichi Koga, Takaomi Okamoto, Tatsuro Suzuki, Akira Nakanishi, Yoichi PICT1 expression is a poor prognostic factor in non-small cell lung cancer |
title | PICT1 expression is a poor prognostic factor in non-small cell lung cancer |
title_full | PICT1 expression is a poor prognostic factor in non-small cell lung cancer |
title_fullStr | PICT1 expression is a poor prognostic factor in non-small cell lung cancer |
title_full_unstemmed | PICT1 expression is a poor prognostic factor in non-small cell lung cancer |
title_short | PICT1 expression is a poor prognostic factor in non-small cell lung cancer |
title_sort | pict1 expression is a poor prognostic factor in non-small cell lung cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278310/ https://www.ncbi.nlm.nih.gov/pubmed/25594032 |
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