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An old friend with new skills: Imiquimod as novel inhibitor of Hedgehog signaling in basal cell carcinoma

Deregulated Hedgehog (HH)/GLI signaling plays an etiologic role in the initiation, progression and maintenance of many cancers. Small molecule targeting of HH signaling by inhibiting the essential pathway effector Smoothened (SMO) has proven exceptionally efficient for the treatment of advanced and...

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Detalles Bibliográficos
Autores principales:	Gruber, Wolfgang, Frischauf, Anna-Maria, Aberger, Fritz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278338/ https://www.ncbi.nlm.nih.gov/pubmed/25594066

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