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Epigenetic and genetic dispositions of ovarian carcinomas
Ovarian clear cell carcinoma has unique clinical characteristics with slow growth and a stress-resistant phenotype that is epigenetically induced during cancer progression in an inflammatory microenvironment. We refer to this as an epigenetic disposition, which is frequently associated with unique b...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278339/ https://www.ncbi.nlm.nih.gov/pubmed/25594067 |
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author | Yamaguchi, Ken Matsumura, Noriomi Mandai, Masaki Baba, Tsukasa Konishi, Ikuo Murphy, Susan K |
author_facet | Yamaguchi, Ken Matsumura, Noriomi Mandai, Masaki Baba, Tsukasa Konishi, Ikuo Murphy, Susan K |
author_sort | Yamaguchi, Ken |
collection | PubMed |
description | Ovarian clear cell carcinoma has unique clinical characteristics with slow growth and a stress-resistant phenotype that is epigenetically induced during cancer progression in an inflammatory microenvironment. We refer to this as an epigenetic disposition, which is frequently associated with unique biomolecular features including prominent alterations in methylation, microsatellite instability and ARID1A mutations. This characteristic methylation profile also affects glucose metabolism, commonly known as the Warburg effect. In contrast, high-grade ovarian serous adenocarcinoma has a genetic disposition that is accompanied by rapid growth, TP53 mutations and chromosomal instability. The concept of epigenetic and genetic dispositions is applicable to various malignancies, including gastric and colorectal cancers. These disposition classifications are based on fundamental characteristics of malignancies and may provide a new vantage point for development of individualized therapies. |
format | Online Article Text |
id | pubmed-4278339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-42783392015-01-15 Epigenetic and genetic dispositions of ovarian carcinomas Yamaguchi, Ken Matsumura, Noriomi Mandai, Masaki Baba, Tsukasa Konishi, Ikuo Murphy, Susan K Oncoscience Research Perspective Ovarian clear cell carcinoma has unique clinical characteristics with slow growth and a stress-resistant phenotype that is epigenetically induced during cancer progression in an inflammatory microenvironment. We refer to this as an epigenetic disposition, which is frequently associated with unique biomolecular features including prominent alterations in methylation, microsatellite instability and ARID1A mutations. This characteristic methylation profile also affects glucose metabolism, commonly known as the Warburg effect. In contrast, high-grade ovarian serous adenocarcinoma has a genetic disposition that is accompanied by rapid growth, TP53 mutations and chromosomal instability. The concept of epigenetic and genetic dispositions is applicable to various malignancies, including gastric and colorectal cancers. These disposition classifications are based on fundamental characteristics of malignancies and may provide a new vantage point for development of individualized therapies. Impact Journals LLC 2014-09-22 /pmc/articles/PMC4278339/ /pubmed/25594067 Text en © 2014 Yamaguchi et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Perspective Yamaguchi, Ken Matsumura, Noriomi Mandai, Masaki Baba, Tsukasa Konishi, Ikuo Murphy, Susan K Epigenetic and genetic dispositions of ovarian carcinomas |
title | Epigenetic and genetic dispositions of ovarian carcinomas |
title_full | Epigenetic and genetic dispositions of ovarian carcinomas |
title_fullStr | Epigenetic and genetic dispositions of ovarian carcinomas |
title_full_unstemmed | Epigenetic and genetic dispositions of ovarian carcinomas |
title_short | Epigenetic and genetic dispositions of ovarian carcinomas |
title_sort | epigenetic and genetic dispositions of ovarian carcinomas |
topic | Research Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278339/ https://www.ncbi.nlm.nih.gov/pubmed/25594067 |
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