Methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (AhR) signaling

Alkylated polycyclic aromatic hydrocarbons (APAHs) are abundant in petroleum, but data regarding their toxicological properties are limited. A survey of all monomethylated phenanthrene structures revealed that they were 2 times to 5 times more potent than phenanthrene for activation of human aryl hy...

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Detalles Bibliográficos
Autores principales: Sun, Yue, Miller, Charles A, Wiese, Thomas E, Blake, Diane A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc 2014
Materias:
Environmental Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278532/
https://www.ncbi.nlm.nih.gov/pubmed/25043914
http://dx.doi.org/10.1002/etc.2687
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author Sun, Yue
Miller, Charles A
Wiese, Thomas E
Blake, Diane A
author_facet Sun, Yue
Miller, Charles A
Wiese, Thomas E
Blake, Diane A
author_sort Sun, Yue
collection PubMed
description Alkylated polycyclic aromatic hydrocarbons (APAHs) are abundant in petroleum, but data regarding their toxicological properties are limited. A survey of all monomethylated phenanthrene structures revealed that they were 2 times to 5 times more potent than phenanthrene for activation of human aryl hydrocarbon receptor in a yeast bioassay. Phenanthrenes with equatorial methyl groups had the greatest potency. The greater potency of the methylated phenanthrenes highlights the need for more toxicological data on APAHs. Environ Toxicol Chem 2014;33:2363–2367.
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spelling pubmed-42785322014-12-31 Methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (AhR) signaling Sun, Yue Miller, Charles A Wiese, Thomas E Blake, Diane A Environ Toxicol Chem Environmental Toxicology Alkylated polycyclic aromatic hydrocarbons (APAHs) are abundant in petroleum, but data regarding their toxicological properties are limited. A survey of all monomethylated phenanthrene structures revealed that they were 2 times to 5 times more potent than phenanthrene for activation of human aryl hydrocarbon receptor in a yeast bioassay. Phenanthrenes with equatorial methyl groups had the greatest potency. The greater potency of the methylated phenanthrenes highlights the need for more toxicological data on APAHs. Environ Toxicol Chem 2014;33:2363–2367. Wiley Periodicals, Inc 2014-10 2014-08-25 /pmc/articles/PMC4278532/ /pubmed/25043914 http://dx.doi.org/10.1002/etc.2687 Text en © 2014 The Authors. Environmental Toxicology and Chemistry Published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Environmental Toxicology
Sun, Yue
Miller, Charles A
Wiese, Thomas E
Blake, Diane A
Methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (AhR) signaling
title Methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (AhR) signaling
title_full Methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (AhR) signaling
title_fullStr Methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (AhR) signaling
title_full_unstemmed Methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (AhR) signaling
title_short Methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (AhR) signaling
title_sort methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (ahr) signaling
topic Environmental Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278532/
https://www.ncbi.nlm.nih.gov/pubmed/25043914
http://dx.doi.org/10.1002/etc.2687
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AT wiesethomase methylatedphenanthrenesaremorepotentthanphenanthreneinabioassayofhumanarylhydrocarbonreceptorahrsignaling
AT blakedianea methylatedphenanthrenesaremorepotentthanphenanthreneinabioassayofhumanarylhydrocarbonreceptorahrsignaling

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