Human Papillomavirus E6 Triggers Upregulation of the Antiviral and Cancer Genomic DNA Deaminase APOBEC3B

Several recent studies have converged upon the innate immune DNA cytosine deaminase APOBEC3B (A3B) as a significant source of genomic uracil lesions and mutagenesis in multiple human cancers, including those of the breast, head/neck, cervix, bladder, lung, ovary, and other tissues. A3B is upregulate...

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Detalles Bibliográficos
Autores principales: Vieira, Valdimara C., Leonard, Brandon, White, Elizabeth A., Starrett, Gabriel J., Temiz, Nuri A., Lorenz, Laurel D., Lee, Denis, Soares, Marcelo A., Lambert, Paul F., Howley, Peter M., Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278539/
https://www.ncbi.nlm.nih.gov/pubmed/25538195
http://dx.doi.org/10.1128/mBio.02234-14

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