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Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness

In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to...

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Autores principales: Schultz-Cherry, S., Webby, R. J., Webster, R. G., Kelso, A., Barr, I. G., McCauley, J. W., Daniels, R. S., Wang, D., Shu, Y., Nobusawa, E., Itamura, S., Tashiro, M., Harada, Y., Watanabe, S., Odagiri, T., Ye, Z., Grohmann, G., Harvey, R., Engelhardt, O., Smith, D., Hamilton, K., Claes, F., Dauphin, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278542/
https://www.ncbi.nlm.nih.gov/pubmed/25505124
http://dx.doi.org/10.1128/mBio.02430-14
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author Schultz-Cherry, S.
Webby, R. J.
Webster, R. G.
Kelso, A.
Barr, I. G.
McCauley, J. W.
Daniels, R. S.
Wang, D.
Shu, Y.
Nobusawa, E.
Itamura, S.
Tashiro, M.
Harada, Y.
Watanabe, S.
Odagiri, T.
Ye, Z.
Grohmann, G.
Harvey, R.
Engelhardt, O.
Smith, D.
Hamilton, K.
Claes, F.
Dauphin, G.
author_facet Schultz-Cherry, S.
Webby, R. J.
Webster, R. G.
Kelso, A.
Barr, I. G.
McCauley, J. W.
Daniels, R. S.
Wang, D.
Shu, Y.
Nobusawa, E.
Itamura, S.
Tashiro, M.
Harada, Y.
Watanabe, S.
Odagiri, T.
Ye, Z.
Grohmann, G.
Harvey, R.
Engelhardt, O.
Smith, D.
Hamilton, K.
Claes, F.
Dauphin, G.
author_sort Schultz-Cherry, S.
collection PubMed
description In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process.
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spelling pubmed-42785422014-12-31 Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness Schultz-Cherry, S. Webby, R. J. Webster, R. G. Kelso, A. Barr, I. G. McCauley, J. W. Daniels, R. S. Wang, D. Shu, Y. Nobusawa, E. Itamura, S. Tashiro, M. Harada, Y. Watanabe, S. Odagiri, T. Ye, Z. Grohmann, G. Harvey, R. Engelhardt, O. Smith, D. Hamilton, K. Claes, F. Dauphin, G. mBio Guest Editorial In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process. American Society of Microbiology 2014-12-12 /pmc/articles/PMC4278542/ /pubmed/25505124 http://dx.doi.org/10.1128/mBio.02430-14 Text en Copyright © 2014 Schultz-Cherry et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Guest Editorial
Schultz-Cherry, S.
Webby, R. J.
Webster, R. G.
Kelso, A.
Barr, I. G.
McCauley, J. W.
Daniels, R. S.
Wang, D.
Shu, Y.
Nobusawa, E.
Itamura, S.
Tashiro, M.
Harada, Y.
Watanabe, S.
Odagiri, T.
Ye, Z.
Grohmann, G.
Harvey, R.
Engelhardt, O.
Smith, D.
Hamilton, K.
Claes, F.
Dauphin, G.
Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
title Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
title_full Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
title_fullStr Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
title_full_unstemmed Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
title_short Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
title_sort influenza gain-of-function experiments: their role in vaccine virus recommendation and pandemic preparedness
topic Guest Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278542/
https://www.ncbi.nlm.nih.gov/pubmed/25505124
http://dx.doi.org/10.1128/mBio.02430-14
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