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Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Microbiology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278542/ https://www.ncbi.nlm.nih.gov/pubmed/25505124 http://dx.doi.org/10.1128/mBio.02430-14 |
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author | Schultz-Cherry, S. Webby, R. J. Webster, R. G. Kelso, A. Barr, I. G. McCauley, J. W. Daniels, R. S. Wang, D. Shu, Y. Nobusawa, E. Itamura, S. Tashiro, M. Harada, Y. Watanabe, S. Odagiri, T. Ye, Z. Grohmann, G. Harvey, R. Engelhardt, O. Smith, D. Hamilton, K. Claes, F. Dauphin, G. |
author_facet | Schultz-Cherry, S. Webby, R. J. Webster, R. G. Kelso, A. Barr, I. G. McCauley, J. W. Daniels, R. S. Wang, D. Shu, Y. Nobusawa, E. Itamura, S. Tashiro, M. Harada, Y. Watanabe, S. Odagiri, T. Ye, Z. Grohmann, G. Harvey, R. Engelhardt, O. Smith, D. Hamilton, K. Claes, F. Dauphin, G. |
author_sort | Schultz-Cherry, S. |
collection | PubMed |
description | In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process. |
format | Online Article Text |
id | pubmed-4278542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Society of Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-42785422014-12-31 Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness Schultz-Cherry, S. Webby, R. J. Webster, R. G. Kelso, A. Barr, I. G. McCauley, J. W. Daniels, R. S. Wang, D. Shu, Y. Nobusawa, E. Itamura, S. Tashiro, M. Harada, Y. Watanabe, S. Odagiri, T. Ye, Z. Grohmann, G. Harvey, R. Engelhardt, O. Smith, D. Hamilton, K. Claes, F. Dauphin, G. mBio Guest Editorial In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process. American Society of Microbiology 2014-12-12 /pmc/articles/PMC4278542/ /pubmed/25505124 http://dx.doi.org/10.1128/mBio.02430-14 Text en Copyright © 2014 Schultz-Cherry et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) . |
spellingShingle | Guest Editorial Schultz-Cherry, S. Webby, R. J. Webster, R. G. Kelso, A. Barr, I. G. McCauley, J. W. Daniels, R. S. Wang, D. Shu, Y. Nobusawa, E. Itamura, S. Tashiro, M. Harada, Y. Watanabe, S. Odagiri, T. Ye, Z. Grohmann, G. Harvey, R. Engelhardt, O. Smith, D. Hamilton, K. Claes, F. Dauphin, G. Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness |
title | Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness |
title_full | Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness |
title_fullStr | Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness |
title_full_unstemmed | Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness |
title_short | Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness |
title_sort | influenza gain-of-function experiments: their role in vaccine virus recommendation and pandemic preparedness |
topic | Guest Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278542/ https://www.ncbi.nlm.nih.gov/pubmed/25505124 http://dx.doi.org/10.1128/mBio.02430-14 |
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