Adjuvant Effects Elicited by Novel Oligosaccharide Variants of Detoxified Meningococcal Lipopolysaccharides on Neisseria meningitidis Recombinant PorA Protein: A Comparison in Mice

Neisseria meningitidis lipopolysaccharide (LPS) has adjuvant properties that can be exploited to assist vaccine immunogenicity. The modified penta-acylated LPS retains the adjuvant properties of hexa-acylated LPS but has a reduced toxicity profile. In this study we investigated whether two modified...

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Detalles Bibliográficos
Autores principales: Mehta, Ojas H., Norheim, Gunnstein, Hoe, J . Claire, Rollier, Christine S., Nagaputra, Jerry C., Makepeace, Katherine, Saleem, Muhammad, Chan, Hannah, Ferguson, David J. P., Jones, Claire, Sadarangani, Manish, Hood, Derek W., Feavers, Ian, Derrick, Jeremy P., Pollard, Andrew J., Moxon, E . Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278719/
https://www.ncbi.nlm.nih.gov/pubmed/25545241
http://dx.doi.org/10.1371/journal.pone.0115713

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