MABGEL 1: First Phase 1 Trial of the Anti-HIV-1 Monoclonal Antibodies 2F5, 4E10 and 2G12 as a Vaginal Microbicide

BACKGROUND: Monoclonal antibodies (mAbs) which potently neutralize a broad range of HIV isolates are potential microbicide candidates. To date, topical application of mAbs in humans and their stability in vaginal secretions has not been studied. OBJECTIVES: To assess the pharmacokinetics and safety...

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Detalles Bibliográficos
Autores principales: Morris, Georgina C., Wiggins, Rebecca C., Woodhall, Sarah C., Bland, J. Martin, Taylor, Carol R., Jespers, Vicky, Vcelar, Brigitta A., Lacey, Charles J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278856/
https://www.ncbi.nlm.nih.gov/pubmed/25546420
http://dx.doi.org/10.1371/journal.pone.0116153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278856/
https://www.ncbi.nlm.nih.gov/pubmed/25546420
http://dx.doi.org/10.1371/journal.pone.0116153

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