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Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases
Inflammatory disease management poses challenges due to the complexity of inflammation and inherent patient variability, thereby necessitating patient-specific therapeutic interventions. Theranostics, which integrate therapeutic and imaging functionalities, can be used for simultaneous imaging and t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279001/ https://www.ncbi.nlm.nih.gov/pubmed/25553105 http://dx.doi.org/10.7150/thno.9476 |
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author | Patel, Sravan Kumar Janjic, Jelena M. |
author_facet | Patel, Sravan Kumar Janjic, Jelena M. |
author_sort | Patel, Sravan Kumar |
collection | PubMed |
description | Inflammatory disease management poses challenges due to the complexity of inflammation and inherent patient variability, thereby necessitating patient-specific therapeutic interventions. Theranostics, which integrate therapeutic and imaging functionalities, can be used for simultaneous imaging and treatment of inflammatory diseases. Theranostics could facilitate assessment of safety, toxicity and real-time therapeutic efficacy leading to personalized treatment strategies. Macrophages are an important cellular component of inflammatory diseases, participating in varied roles of disease exacerbation and resolution. The inherent phagocytic nature, abundance and disease homing properties of macrophages can be targeted for imaging and therapeutic purposes. This review discusses the utility of theranostics in macrophage ablation, phenotype modulation and inhibition of their inflammatory activity leading to resolution of inflammation in several diseases. |
format | Online Article Text |
id | pubmed-4279001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-42790012015-01-01 Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases Patel, Sravan Kumar Janjic, Jelena M. Theranostics Review Inflammatory disease management poses challenges due to the complexity of inflammation and inherent patient variability, thereby necessitating patient-specific therapeutic interventions. Theranostics, which integrate therapeutic and imaging functionalities, can be used for simultaneous imaging and treatment of inflammatory diseases. Theranostics could facilitate assessment of safety, toxicity and real-time therapeutic efficacy leading to personalized treatment strategies. Macrophages are an important cellular component of inflammatory diseases, participating in varied roles of disease exacerbation and resolution. The inherent phagocytic nature, abundance and disease homing properties of macrophages can be targeted for imaging and therapeutic purposes. This review discusses the utility of theranostics in macrophage ablation, phenotype modulation and inhibition of their inflammatory activity leading to resolution of inflammation in several diseases. Ivyspring International Publisher 2015-01-01 /pmc/articles/PMC4279001/ /pubmed/25553105 http://dx.doi.org/10.7150/thno.9476 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Review Patel, Sravan Kumar Janjic, Jelena M. Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases |
title | Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases |
title_full | Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases |
title_fullStr | Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases |
title_full_unstemmed | Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases |
title_short | Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases |
title_sort | macrophage targeted theranostics as personalized nanomedicine strategies for inflammatory diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279001/ https://www.ncbi.nlm.nih.gov/pubmed/25553105 http://dx.doi.org/10.7150/thno.9476 |
work_keys_str_mv | AT patelsravankumar macrophagetargetedtheranosticsaspersonalizednanomedicinestrategiesforinflammatorydiseases AT janjicjelenam macrophagetargetedtheranosticsaspersonalizednanomedicinestrategiesforinflammatorydiseases |