Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis

IL-27, a heterodimeric cytokine of IL-12 family, regulates both innate and adaptive immunity largely via Jak-Stat signaling. IL-27 can induce IFN-γ and inflammatory mediators from T lymphocytes and innate immune cells. IL-27 has unique anti-inflammatory properties via both Tr1 cells dependent and in...

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Autores principales: Abdalla, Abualgasim Elgaili, Li, Qiming, Xie, Longxiang, Xie, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279092/
https://www.ncbi.nlm.nih.gov/pubmed/25561899
http://dx.doi.org/10.7150/ijbs.10464
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author Abdalla, Abualgasim Elgaili
Li, Qiming
Xie, Longxiang
Xie, Jianping
author_facet Abdalla, Abualgasim Elgaili
Li, Qiming
Xie, Longxiang
Xie, Jianping
author_sort Abdalla, Abualgasim Elgaili
collection PubMed
description IL-27, a heterodimeric cytokine of IL-12 family, regulates both innate and adaptive immunity largely via Jak-Stat signaling. IL-27 can induce IFN-γ and inflammatory mediators from T lymphocytes and innate immune cells. IL-27 has unique anti-inflammatory properties via both Tr1 cells dependent and independent mechanisms. Here the role and biology of IL-27 in innate and adaptive immunity are summarized, with special interest with immunity against Mycobacterium tuberculosis.
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spelling pubmed-42790922015-01-05 Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis Abdalla, Abualgasim Elgaili Li, Qiming Xie, Longxiang Xie, Jianping Int J Biol Sci Review IL-27, a heterodimeric cytokine of IL-12 family, regulates both innate and adaptive immunity largely via Jak-Stat signaling. IL-27 can induce IFN-γ and inflammatory mediators from T lymphocytes and innate immune cells. IL-27 has unique anti-inflammatory properties via both Tr1 cells dependent and independent mechanisms. Here the role and biology of IL-27 in innate and adaptive immunity are summarized, with special interest with immunity against Mycobacterium tuberculosis. Ivyspring International Publisher 2015-01-05 /pmc/articles/PMC4279092/ /pubmed/25561899 http://dx.doi.org/10.7150/ijbs.10464 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
Abdalla, Abualgasim Elgaili
Li, Qiming
Xie, Longxiang
Xie, Jianping
Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
title Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
title_full Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
title_fullStr Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
title_full_unstemmed Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
title_short Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
title_sort biology of il-27 and its role in the host immunity against mycobacterium tuberculosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279092/
https://www.ncbi.nlm.nih.gov/pubmed/25561899
http://dx.doi.org/10.7150/ijbs.10464
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