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Neural Correlates of Amusia in Williams Syndrome
Congenital amusia is defined by marked deficits in pitch perception and production. Though historically examined only in otherwise typically developing (TD) populations, amusia has recently been documented in Williams syndrome (WS), a genetic, neurodevelopmental disorder with a unique auditory pheno...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279144/ https://www.ncbi.nlm.nih.gov/pubmed/25422929 http://dx.doi.org/10.3390/brainsci4040594 |
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author | Lense, Miriam D. Dankner, Nathan Pryweller, Jennifer R. Thornton-Wells, Tricia A. Dykens, Elisabeth M. |
author_facet | Lense, Miriam D. Dankner, Nathan Pryweller, Jennifer R. Thornton-Wells, Tricia A. Dykens, Elisabeth M. |
author_sort | Lense, Miriam D. |
collection | PubMed |
description | Congenital amusia is defined by marked deficits in pitch perception and production. Though historically examined only in otherwise typically developing (TD) populations, amusia has recently been documented in Williams syndrome (WS), a genetic, neurodevelopmental disorder with a unique auditory phenotype including auditory sensitivities and increased emotional responsiveness to music but variable musical skill. The current study used structural T1-weighted magnetic resonance imaging and diffusion tensor imaging to examine neural correlates of amusia in 17 individuals with WS (4 of whom met criteria for amusia). Consistent with findings from TD amusics, amusia in WS was associated with decreased fractional anisotropy (FA) in the right superior longitudinal fasciculus (SLF). The relationship between amusia and FA in the inferior component of the SLF was particularly robust, withstanding corrections for cognitive functioning, auditory sensitivities, or musical training. Though the number of individuals with amusia in the study is small, results add to evidence for the role of fronto-temporal disconnectivity in congenital amusia and suggest that novel populations with developmental differences can provide a window into understanding gene-brain-behavior relationships that underlie musical behaviors. |
format | Online Article Text |
id | pubmed-4279144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42791442014-12-30 Neural Correlates of Amusia in Williams Syndrome Lense, Miriam D. Dankner, Nathan Pryweller, Jennifer R. Thornton-Wells, Tricia A. Dykens, Elisabeth M. Brain Sci Article Congenital amusia is defined by marked deficits in pitch perception and production. Though historically examined only in otherwise typically developing (TD) populations, amusia has recently been documented in Williams syndrome (WS), a genetic, neurodevelopmental disorder with a unique auditory phenotype including auditory sensitivities and increased emotional responsiveness to music but variable musical skill. The current study used structural T1-weighted magnetic resonance imaging and diffusion tensor imaging to examine neural correlates of amusia in 17 individuals with WS (4 of whom met criteria for amusia). Consistent with findings from TD amusics, amusia in WS was associated with decreased fractional anisotropy (FA) in the right superior longitudinal fasciculus (SLF). The relationship between amusia and FA in the inferior component of the SLF was particularly robust, withstanding corrections for cognitive functioning, auditory sensitivities, or musical training. Though the number of individuals with amusia in the study is small, results add to evidence for the role of fronto-temporal disconnectivity in congenital amusia and suggest that novel populations with developmental differences can provide a window into understanding gene-brain-behavior relationships that underlie musical behaviors. MDPI 2014-11-21 /pmc/articles/PMC4279144/ /pubmed/25422929 http://dx.doi.org/10.3390/brainsci4040594 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lense, Miriam D. Dankner, Nathan Pryweller, Jennifer R. Thornton-Wells, Tricia A. Dykens, Elisabeth M. Neural Correlates of Amusia in Williams Syndrome |
title | Neural Correlates of Amusia in Williams Syndrome |
title_full | Neural Correlates of Amusia in Williams Syndrome |
title_fullStr | Neural Correlates of Amusia in Williams Syndrome |
title_full_unstemmed | Neural Correlates of Amusia in Williams Syndrome |
title_short | Neural Correlates of Amusia in Williams Syndrome |
title_sort | neural correlates of amusia in williams syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279144/ https://www.ncbi.nlm.nih.gov/pubmed/25422929 http://dx.doi.org/10.3390/brainsci4040594 |
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