Cell survival is dicey without Dicer

The cellular requirements for Dicer, an essential miRNA processing enzyme, and the consequences of altered levels of its expression on tumorigenesis are incompletely understood. We review the effects of Dicer loss in cells of different origin and whether loss of p53 permits cell survival and growth...

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Detalles Bibliográficos
Autores principales: Adams, Clare M, Eischen, Christine M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279215/
https://www.ncbi.nlm.nih.gov/pubmed/25558471
http://dx.doi.org/10.4161/23723548.2014.961825
Descripción
Sumario:The cellular requirements for Dicer, an essential miRNA processing enzyme, and the consequences of altered levels of its expression on tumorigenesis are incompletely understood. We review the effects of Dicer loss in cells of different origin and whether loss of p53 permits cell survival and growth in the absence of Dicer.

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