Cell survival is dicey without Dicer

The cellular requirements for Dicer, an essential miRNA processing enzyme, and the consequences of altered levels of its expression on tumorigenesis are incompletely understood. We review the effects of Dicer loss in cells of different origin and whether loss of p53 permits cell survival and growth...

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Detalles Bibliográficos
Autores principales: Adams, Clare M, Eischen, Christine M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279215/
https://www.ncbi.nlm.nih.gov/pubmed/25558471
http://dx.doi.org/10.4161/23723548.2014.961825
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author Adams, Clare M
Eischen, Christine M
author_facet Adams, Clare M
Eischen, Christine M
author_sort Adams, Clare M
collection PubMed
description The cellular requirements for Dicer, an essential miRNA processing enzyme, and the consequences of altered levels of its expression on tumorigenesis are incompletely understood. We review the effects of Dicer loss in cells of different origin and whether loss of p53 permits cell survival and growth in the absence of Dicer.
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spelling pubmed-42792152015-06-01 Cell survival is dicey without Dicer Adams, Clare M Eischen, Christine M Mol Cell Oncol Author's View The cellular requirements for Dicer, an essential miRNA processing enzyme, and the consequences of altered levels of its expression on tumorigenesis are incompletely understood. We review the effects of Dicer loss in cells of different origin and whether loss of p53 permits cell survival and growth in the absence of Dicer. Taylor & Francis 2014-10-29 /pmc/articles/PMC4279215/ /pubmed/25558471 http://dx.doi.org/10.4161/23723548.2014.961825 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Adams, Clare M
Eischen, Christine M
Cell survival is dicey without Dicer
title Cell survival is dicey without Dicer
title_full Cell survival is dicey without Dicer
title_fullStr Cell survival is dicey without Dicer
title_full_unstemmed Cell survival is dicey without Dicer
title_short Cell survival is dicey without Dicer
title_sort cell survival is dicey without dicer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279215/
https://www.ncbi.nlm.nih.gov/pubmed/25558471
http://dx.doi.org/10.4161/23723548.2014.961825
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