COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

COMMD1 deficiency results in defective copper homeostasis, but the mechanism for this has remained elusive. Here we report that COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62. This COMMD/CCDC22/CCDC93 (CCC) complex...

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Detalles Bibliográficos
Autores principales: Phillips-Krawczak, Christine A., Singla, Amika, Starokadomskyy, Petro, Deng, Zhihui, Osborne, Douglas G., Li, Haiying, Dick, Christopher J., Gomez, Timothy S., Koenecke, Megan, Zhang, Jin-San, Dai, Haiming, Sifuentes-Dominguez, Luis F., Geng, Linda N., Kaufmann, Scott H., Hein, Marco Y., Wallis, Mathew, McGaughran, Julie, Gecz, Jozef, van de Sluis, Bart, Billadeau, Daniel D., Burstein, Ezra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279232/
https://www.ncbi.nlm.nih.gov/pubmed/25355947
http://dx.doi.org/10.1091/mbc.E14-06-1073

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