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HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models

The preventative effects of antiretroviral therapy for people with HIV have been debated since they were first raised. Models commenced studying the preventive effects of treatment in the 1990s, prior to initial public reports. However, the outcomes of the preventive effects of antiretroviral use we...

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Detalles Bibliográficos
Autores principales: Wu, Jing, Norris, Jessie L., Jia, Yujiang, Wang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279253/
https://www.ncbi.nlm.nih.gov/pubmed/25580461
http://dx.doi.org/10.1155/2014/760734
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author Wu, Jing
Norris, Jessie L.
Jia, Yujiang
Wang, Ning
author_facet Wu, Jing
Norris, Jessie L.
Jia, Yujiang
Wang, Ning
author_sort Wu, Jing
collection PubMed
description The preventative effects of antiretroviral therapy for people with HIV have been debated since they were first raised. Models commenced studying the preventive effects of treatment in the 1990s, prior to initial public reports. However, the outcomes of the preventive effects of antiretroviral use were not consistent. Some outcomes of dynamic models were based on unfeasible assumptions, such as no consideration of drug resistance, behavior disinhibition, or economic inputs in poor countries, and unrealistic input variables, for example, overstated initiation time, adherence, coverage, and efficacy of treatment. This paper reviewed dynamic mathematical models to ascertain the complex effects of ART on HIV transmission. This review discusses more conservative inputs and outcomes relative to antiretroviral use in HIV infections in dynamic mathematical models. ART alone cannot eliminate HIV transmission.
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spelling pubmed-42792532015-01-11 HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models Wu, Jing Norris, Jessie L. Jia, Yujiang Wang, Ning ScientificWorldJournal Review Article The preventative effects of antiretroviral therapy for people with HIV have been debated since they were first raised. Models commenced studying the preventive effects of treatment in the 1990s, prior to initial public reports. However, the outcomes of the preventive effects of antiretroviral use were not consistent. Some outcomes of dynamic models were based on unfeasible assumptions, such as no consideration of drug resistance, behavior disinhibition, or economic inputs in poor countries, and unrealistic input variables, for example, overstated initiation time, adherence, coverage, and efficacy of treatment. This paper reviewed dynamic mathematical models to ascertain the complex effects of ART on HIV transmission. This review discusses more conservative inputs and outcomes relative to antiretroviral use in HIV infections in dynamic mathematical models. ART alone cannot eliminate HIV transmission. Hindawi Publishing Corporation 2014 2014-12-15 /pmc/articles/PMC4279253/ /pubmed/25580461 http://dx.doi.org/10.1155/2014/760734 Text en Copyright © 2014 Jing Wu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wu, Jing
Norris, Jessie L.
Jia, Yujiang
Wang, Ning
HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models
title HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models
title_full HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models
title_fullStr HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models
title_full_unstemmed HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models
title_short HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models
title_sort hiv treatment as prevention: contradictory perspectives from dynamic mathematical models
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279253/
https://www.ncbi.nlm.nih.gov/pubmed/25580461
http://dx.doi.org/10.1155/2014/760734
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