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Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies
A trillion of microorganisms colonize the mammalian intestine. Most of them have coevolved with the host in a symbiotic relationship and some of them have developed strategies to promote their replication in the presence of competing microbiota. Recent evidence suggests that perturbation of the micr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279263/ https://www.ncbi.nlm.nih.gov/pubmed/25580435 http://dx.doi.org/10.1155/2014/567929 |
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author | Agus, Allison Massier, Sébastien Darfeuille-Michaud, Arlette Billard, Elisabeth Barnich, Nicolas |
author_facet | Agus, Allison Massier, Sébastien Darfeuille-Michaud, Arlette Billard, Elisabeth Barnich, Nicolas |
author_sort | Agus, Allison |
collection | PubMed |
description | A trillion of microorganisms colonize the mammalian intestine. Most of them have coevolved with the host in a symbiotic relationship and some of them have developed strategies to promote their replication in the presence of competing microbiota. Recent evidence suggests that perturbation of the microbial community favors the emergence of opportunistic pathogens, in particular adherent-invasive Escherichia coli (AIEC) that can increase incidence and severity of gut inflammation in the context of Crohn's disease (CD). This review will report the importance of AIEC as triggers of intestinal inflammation, focusing on their impact on epithelial barrier function and stimulation of mucosal inflammation. Beyond manipulation of immune response, restoration of gut microbiota as a new treatment option for CD patients will be discussed. |
format | Online Article Text |
id | pubmed-4279263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42792632015-01-11 Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies Agus, Allison Massier, Sébastien Darfeuille-Michaud, Arlette Billard, Elisabeth Barnich, Nicolas Biomed Res Int Review Article A trillion of microorganisms colonize the mammalian intestine. Most of them have coevolved with the host in a symbiotic relationship and some of them have developed strategies to promote their replication in the presence of competing microbiota. Recent evidence suggests that perturbation of the microbial community favors the emergence of opportunistic pathogens, in particular adherent-invasive Escherichia coli (AIEC) that can increase incidence and severity of gut inflammation in the context of Crohn's disease (CD). This review will report the importance of AIEC as triggers of intestinal inflammation, focusing on their impact on epithelial barrier function and stimulation of mucosal inflammation. Beyond manipulation of immune response, restoration of gut microbiota as a new treatment option for CD patients will be discussed. Hindawi Publishing Corporation 2014 2014-12-15 /pmc/articles/PMC4279263/ /pubmed/25580435 http://dx.doi.org/10.1155/2014/567929 Text en Copyright © 2014 Allison Agus et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Agus, Allison Massier, Sébastien Darfeuille-Michaud, Arlette Billard, Elisabeth Barnich, Nicolas Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies |
title | Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies |
title_full | Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies |
title_fullStr | Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies |
title_full_unstemmed | Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies |
title_short | Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies |
title_sort | understanding host-adherent-invasive escherichia coli interaction in crohn's disease: opening up new therapeutic strategies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279263/ https://www.ncbi.nlm.nih.gov/pubmed/25580435 http://dx.doi.org/10.1155/2014/567929 |
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