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Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients
BACKGROUND: Blood loss is often a major complication in neurosurgery that requires transfusion of multiple units of blood. The purpose of this study was to assess the effect of tranexamic acid (TXA) on intraoperative blood loss and the need for blood transfusion in patients undergoing craniotomy for...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279349/ https://www.ncbi.nlm.nih.gov/pubmed/25558198 http://dx.doi.org/10.4103/1658-354X.146304 |
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author | Vel, Ramya Udupi, Bidkar Prasanna Satya Prakash, Munaganuri Venkata Siva Adinarayanan, Sethuramachandran Mishra, Sandeep Babu, Lenin |
author_facet | Vel, Ramya Udupi, Bidkar Prasanna Satya Prakash, Munaganuri Venkata Siva Adinarayanan, Sethuramachandran Mishra, Sandeep Babu, Lenin |
author_sort | Vel, Ramya |
collection | PubMed |
description | BACKGROUND: Blood loss is often a major complication in neurosurgery that requires transfusion of multiple units of blood. The purpose of this study was to assess the effect of tranexamic acid (TXA) on intraoperative blood loss and the need for blood transfusion in patients undergoing craniotomy for tumor excision. MATERIALS AND METHODS: A total of 100 patients aged 18-60 years, with American Society of Anesthesiologists physical Status 1 and 2 scheduled to undergo elective craniotomy for tumor excision were enrolled. Patients received 10 mg/kg bolus about 20 min before skin incision followed by 1 mg/kg/h infusion of either TXA or saline. Hemodynamic variables, intravenous fluid transfused, amount of blood loss and blood given were measured every 2 h. Laboratory parameters such as serum electrolytes and fibrinogen values were measured every 3 h. On the 5(th) postoperative day hemoglobin (POD Hb5), Hb estimation was done and the estimated blood loss (EBL) calculated. Patients were also monitored for any complications. RESULTS: The Mean heart rate in TXA group was significantly lower compared with the saline group. Mean arterial pressure and fibrinogen levels were higher in TXA group. The mean total blood loss in the TXA group was less than in the saline group. Blood transfusion requirements were comparable in two groups. The EBL and POD5 Hb were comparable in two groups. CONCLUSION: Even though, there is a significant reduction in the total amount of blood loss in TXA group. However, there was no reduction in intraoperative transfusion requirement. |
format | Online Article Text |
id | pubmed-4279349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42793492015-01-02 Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients Vel, Ramya Udupi, Bidkar Prasanna Satya Prakash, Munaganuri Venkata Siva Adinarayanan, Sethuramachandran Mishra, Sandeep Babu, Lenin Saudi J Anaesth Original Article BACKGROUND: Blood loss is often a major complication in neurosurgery that requires transfusion of multiple units of blood. The purpose of this study was to assess the effect of tranexamic acid (TXA) on intraoperative blood loss and the need for blood transfusion in patients undergoing craniotomy for tumor excision. MATERIALS AND METHODS: A total of 100 patients aged 18-60 years, with American Society of Anesthesiologists physical Status 1 and 2 scheduled to undergo elective craniotomy for tumor excision were enrolled. Patients received 10 mg/kg bolus about 20 min before skin incision followed by 1 mg/kg/h infusion of either TXA or saline. Hemodynamic variables, intravenous fluid transfused, amount of blood loss and blood given were measured every 2 h. Laboratory parameters such as serum electrolytes and fibrinogen values were measured every 3 h. On the 5(th) postoperative day hemoglobin (POD Hb5), Hb estimation was done and the estimated blood loss (EBL) calculated. Patients were also monitored for any complications. RESULTS: The Mean heart rate in TXA group was significantly lower compared with the saline group. Mean arterial pressure and fibrinogen levels were higher in TXA group. The mean total blood loss in the TXA group was less than in the saline group. Blood transfusion requirements were comparable in two groups. The EBL and POD5 Hb were comparable in two groups. CONCLUSION: Even though, there is a significant reduction in the total amount of blood loss in TXA group. However, there was no reduction in intraoperative transfusion requirement. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4279349/ /pubmed/25558198 http://dx.doi.org/10.4103/1658-354X.146304 Text en Copyright: © Saudi Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Vel, Ramya Udupi, Bidkar Prasanna Satya Prakash, Munaganuri Venkata Siva Adinarayanan, Sethuramachandran Mishra, Sandeep Babu, Lenin Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients |
title | Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients |
title_full | Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients |
title_fullStr | Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients |
title_full_unstemmed | Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients |
title_short | Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients |
title_sort | effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279349/ https://www.ncbi.nlm.nih.gov/pubmed/25558198 http://dx.doi.org/10.4103/1658-354X.146304 |
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