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Regulation of ERBB3/HER3 signaling in cancer
ERBB3/HER3 is emerging as a molecular target for various cancers. HER3 is overexpressed and activated in a number of cancer types under the conditions of acquired resistance to other HER family therapeutic interventions such as tyrosine kinase inhibitors and antibody therapies. Regulation of the HER...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279368/ https://www.ncbi.nlm.nih.gov/pubmed/25400118 |
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author | Mujoo, Kalpana Choi, Byung-Kwon Huang, Zhao Zhang, Ningyan An, Zhiqiang |
author_facet | Mujoo, Kalpana Choi, Byung-Kwon Huang, Zhao Zhang, Ningyan An, Zhiqiang |
author_sort | Mujoo, Kalpana |
collection | PubMed |
description | ERBB3/HER3 is emerging as a molecular target for various cancers. HER3 is overexpressed and activated in a number of cancer types under the conditions of acquired resistance to other HER family therapeutic interventions such as tyrosine kinase inhibitors and antibody therapies. Regulation of the HER3 expression and signaling involves numerous HER3 interacting proteins. These proteins include PI3K, Shc, and E3 ubiquitin ligases NEDD4 and Nrdp1. Furthermore, recent identification of a number of HER3 oncogenic mutations in colon and gastric cancers elucidate the role of HER3 in cancer development. Despite the strong evidence regarding the role of HER3 in cancer, the current understanding of the regulation of HER3 expression and activation requires additional research. Moreover, the lack of biomarkers for HER3-driven cancer poses a big challenge for the clinical development of HER3 targeting antibodies. Therefore, a better understanding of HER3 regulation should improve the strategies to therapeutically target HER3 for cancer therapy. |
format | Online Article Text |
id | pubmed-4279368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-42793682015-01-06 Regulation of ERBB3/HER3 signaling in cancer Mujoo, Kalpana Choi, Byung-Kwon Huang, Zhao Zhang, Ningyan An, Zhiqiang Oncotarget Review ERBB3/HER3 is emerging as a molecular target for various cancers. HER3 is overexpressed and activated in a number of cancer types under the conditions of acquired resistance to other HER family therapeutic interventions such as tyrosine kinase inhibitors and antibody therapies. Regulation of the HER3 expression and signaling involves numerous HER3 interacting proteins. These proteins include PI3K, Shc, and E3 ubiquitin ligases NEDD4 and Nrdp1. Furthermore, recent identification of a number of HER3 oncogenic mutations in colon and gastric cancers elucidate the role of HER3 in cancer development. Despite the strong evidence regarding the role of HER3 in cancer, the current understanding of the regulation of HER3 expression and activation requires additional research. Moreover, the lack of biomarkers for HER3-driven cancer poses a big challenge for the clinical development of HER3 targeting antibodies. Therefore, a better understanding of HER3 regulation should improve the strategies to therapeutically target HER3 for cancer therapy. Impact Journals LLC 2014-11-02 /pmc/articles/PMC4279368/ /pubmed/25400118 Text en Copyright: © 2014 Mujoo et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Mujoo, Kalpana Choi, Byung-Kwon Huang, Zhao Zhang, Ningyan An, Zhiqiang Regulation of ERBB3/HER3 signaling in cancer |
title | Regulation of ERBB3/HER3 signaling in cancer |
title_full | Regulation of ERBB3/HER3 signaling in cancer |
title_fullStr | Regulation of ERBB3/HER3 signaling in cancer |
title_full_unstemmed | Regulation of ERBB3/HER3 signaling in cancer |
title_short | Regulation of ERBB3/HER3 signaling in cancer |
title_sort | regulation of erbb3/her3 signaling in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279368/ https://www.ncbi.nlm.nih.gov/pubmed/25400118 |
work_keys_str_mv | AT mujookalpana regulationoferbb3her3signalingincancer AT choibyungkwon regulationoferbb3her3signalingincancer AT huangzhao regulationoferbb3her3signalingincancer AT zhangningyan regulationoferbb3her3signalingincancer AT anzhiqiang regulationoferbb3her3signalingincancer |