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Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo

The polycomb group gene, EZH2, is highly expressed in advanced bladder cancer. Here we demonstrated that down-regulation of EZH2 in tumor tissues after neo-adjuvant chemotherapy correlated with good therapeutic response in advanced bladder cancer. We next developed a small molecule, NSC745885, deriv...

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Detalles Bibliográficos
Autores principales:	Tang, Shou-Hung, Huang, Hsu-Shan, Wu, Hong-Ui, Tsai, Yi-Ta, Chuang, Mei-Jen, Yu, Cheng-Ping, Huang, Shih-Ming, Sun, Guang-Huan, Chang, Sun-Yran, Hsiao, Pei-Wen, Yu, Dah-Shyong, Cha, Tai-Lung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279377/ https://www.ncbi.nlm.nih.gov/pubmed/25431950

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