Metformin and erlotinib synergize to inhibit basal breast cancer

Basal-like breast cancers (BBCs) are enriched for increased EGFR expression and decreased expression of PTEN. We found that treatment with metformin and erlotinib synergistically induced apoptosis in a subset of BBC cell lines. The drug combination led to enhanced reduction of EGFR, AKT, S6 and 4EBP...

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Detalles Bibliográficos
Autores principales: Lau, Ying-Ka Ingar, Du, Xing, Reyannavar, Vinayak, Hopkins, Benjamin, Shaw, Jacquelyn, Bessler, Eliana, Thomas, Tiffany, Pires, Maira M., Keniry, Megan, Parsons, Ramon E., Cremers, Serge, Szabolcs, Matthias, Maurer, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279389/
https://www.ncbi.nlm.nih.gov/pubmed/25361177

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