Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer

Histone lysine methylation regulates gene expression and cancer initiation. Bioinformatics analysis suggested that DOT1L, a histone H3-lysine79 (H3K79) methyltransferase, plays a potentially important role in breast cancer. DOT1L inhibition selectively inhibited proliferation, self-renewal, metastat...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Deng, Lisheng, Chen, Fengju, Yao, Yuan, Wu, Bulan, Wei, Liping, Mo, Qianxing, Song, Yongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279401/
https://www.ncbi.nlm.nih.gov/pubmed/25359765

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