Cargando…

Induction of a specific CD8+ T-cell response to cancer/testis antigens by demethylating pre-treatment against osteosarcoma

Conventional non-surgical therapeutic regimens against osteosarcoma are subject to chemoresistance and tumor relapse, and immunotherapy may be promising for this tumor. However, it's hard to find satisfactory epitopes for immunotherapy against osteosarcoma. Cancer/testis antigens (CTAs), such a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Binghao, Zhu, Xiaobing, Sun, Lingling, Yuan, Li, Zhang, Jian, Li, Hengyuan, Ye, Zhaoming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279410/ https://www.ncbi.nlm.nih.gov/pubmed/25301731

Ejemplares similares

Valproic Acid Combined with Zoledronate Enhance γδ T Cell-Mediated Cytotoxicity against Osteosarcoma Cells via the Accumulation of Mevalonate Pathway Intermediates
por: Wang, Shengdong, et al.
Publicado: (2018)

Decitabine Enhances Vγ9Vδ2 T Cell-Mediated Cytotoxic Effects on Osteosarcoma Cells via the NKG2DL–NKG2D Axis
por: Wang, Zhan, et al.
Publicado: (2018)

Three hematological indexes that may serve as prognostic indicators in patients with primary, high-grade, appendicular osteosarcoma
por: Hu, Keqi, et al.
Publicado: (2017)

T-Cell-Based Immunotherapy for Osteosarcoma: Challenges and Opportunities
por: Wang, Zhan, et al.
Publicado: (2016)

Survival Prediction in High-grade Osteosarcoma Using Radiomics of Diagnostic Computed Tomography
por: Wu, Yan, et al.
Publicado: (2018)

Innate Immune Cells: A Potential and Promising Cell Population for Treating Osteosarcoma
por: Wang, Zenan, et al.
Publicado: (2019)

Human γδ T cells induce CD8(+) T cell antitumor responses via antigen-presenting effect through HSP90-MyD88-mediated activation of JNK
por: Wang, Shengdong, et al.
Publicado: (2023)

Andrographolide induces apoptosis in human osteosarcoma cells via the ROS/JNK pathway
por: Wang, Shengdong, et al.
Publicado: (2020)

Demethylation of Cancer/Testis Antigens and CpG ODN Stimulation Enhance Dendritic Cell and Cytotoxic T Lymphocyte Function in a Mouse Mammary Model
por: Sun, Jun-Zhong, et al.
Publicado: (2013)

Spontaneous CD4(+) and CD8(+) T‐cell responses directed against cancer testis antigens are present in the peripheral blood of testicular cancer patients
por: Pearce, Hayden, et al.
Publicado: (2017)

Prognostic factors for survival among patients with primary bone sarcomas of small bones
por: Wang, Zhan, et al.
Publicado: (2018)

Pelvic reconstruction with different rod-screw systems following Enneking type I/I + IV resection: a clinical study
por: Lin, Peng, et al.
Publicado: (2017)

Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas
por: Asano, Naofumi, et al.
Publicado: (2019)

Bone combined cement grafting in giant cell tumor around the knee reduces mechanical failure
por: Teng, Wangsiyuan, et al.
Publicado: (2018)

Clinicopathological assessment of cancer/testis antigens NY-ESO-1 and MAGE-A4 in osteosarcoma
por: Hashimoto, Kazuhiko, et al.
Publicado: (2022)

Oxidative stress induction by narasin augments doxorubicin’s efficacy in osteosarcoma
por: Han, Zhaoming, et al.
Publicado: (2023)

Optimizing Immunization Strategies for the Induction of Antigen-Specific CD4 and CD8 T Cell Responses for Protection against Intracellular Parasites
por: Hofmeyer, Kimberly A., et al.
Publicado: (2016)

KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma
por: Jiang, Yuhang, et al.
Publicado: (2021)

Prognostic value of IGF-1R expression in bone and soft tissue sarcomas: a meta-analysis
por: Liang, Junbo, et al.
Publicado: (2015)

Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis
por: Kristensen, D G, et al.
Publicado: (2014)

Expression of the immune regulation antigen CD70 in osteosarcoma
por: Pahl, Jens HW, et al.
Publicado: (2015)

Cell-permeable capsids as universal antigen carrier for the induction of an antigen-specific CD8(+) T-cell response
por: Akhras, Sami, et al.
Publicado: (2017)

The Induction of Antigen 85B-Specific CD8(+) T Cells by Recombinant BCG Protects against Mycobacterial Infection in Mice
por: Komine-Aizawa, Shihoko, et al.
Publicado: (2023)

Defining rules of CD8(+) T cell expansion against pre-erythrocytic Plasmodium antigens in sporozoite-immunized mice
por: Billman, Zachary P., et al.
Publicado: (2016)

Demethylation of the Coding Region Triggers the Activation of the Human Testis-Specific PDHA2 Gene in Somatic Tissues
por: Pinheiro, Ana, et al.
Publicado: (2012)

SENP3-Mediated PPARγ2 DeSUMOylation in BM-MSCs Potentiates Glucocorticoid-Induced Osteoporosis by Promoting Adipogenesis and Weakening Osteogenesis
por: Zhang, Yongxing, et al.
Publicado: (2021)

Induction of DNMT1-dependent demethylation of SHP-1 by the natural flavonoid compound Baicalein overcame Imatinib-resistance in CML CD34(+) cells
por: Xu, Xuefen, et al.
Publicado: (2023)

Cancer-testis antigen MAGE-C2/CT10 induces spontaneous CD4(+) and CD8(+) T-cell responses in multiple myeloma patients
por: Reinhard, H, et al.
Publicado: (2014)

Cancer testis antigen and immunotherapy
por: Krishnadas, Deepa Kolaseri, et al.
Publicado: (2013)

Anti-osteosarcoma effect of antiserum against cross antigen TPD52 between osteosarcoma and Trichinella spiralis
por: Yue, Tao-Tao, et al.
Publicado: (2021)

Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation
por: Li, Jun, et al.
Publicado: (2021)

Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value
por: Chai, Xupeng, et al.
Publicado: (2021)

Palmitoylated antigens for the induction of anti-tumor CD8(+) T cells and enhanced tumor recognition
por: Stolk, Dorian A., et al.
Publicado: (2021)

Induction of Specific CD8(+) T Cells against Intracellular Bacteria by CD8(+) T-Cell-Oriented Immunization Approaches
por: Nagata, Toshi, et al.
Publicado: (2010)

Denosumab in Giant Cell Tumor of Bone: Current Status and Pitfalls
por: Li, Hengyuan, et al.
Publicado: (2020)

Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and TSDR demethylation
por: Khosravi, Maryam, et al.
Publicado: (2018)

Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL
Publicado: (1996)

Anti-CD40 mAb enhanced efficacy of anti-PD1 against osteosarcoma
por: Zhang, Jingzhe, et al.
Publicado: (2019)

Expression of cancer–testis antigens in esophageal cancer and their progress in immunotherapy
por: Zhang, Yujie, et al.
Publicado: (2019)

Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation
por: Zebley, Caitlin C., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_50jo4tiib1gaskdlrap66clj5p